1-(4-CHLOROPHENYL)-2-NITROETHANE

Base Information

• Chemical Name: 1-(4-CHLOROPHENYL)-2-NITROETHANE
• CAS No.: 60947-43-5
• Molecular Formula: C8H8ClNO2
• Molecular Weight: 185.61
• Hs Code.: 2904909090
• Mol file: 60947-43-5.mol

Synonyms:

Chemical Property of 1-(4-CHLOROPHENYL)-2-NITROETHANE

Chemical Property:

• Melting Point: 111-112 °C
• Boiling Point: 136 °C(Press: 3 Torr)
• PKA: 8.02±0.10(Predicted)
• PSA: 45.82000
• Density: 1.262±0.06 g/cm3(Predicted)
• LogP: 2.68240

Purity/Quality:

95% ^*data from raw suppliers

1-(4-CHLOROPHENYL)-2-NITROETHANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-CHLOROPHENYL)-2-NITROETHANE

There total 9 articles about 1-(4-CHLOROPHENYL)-2-NITROETHANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-chloro-4-(2-nitrovinyl)benzene (706-07-0,5153-70-8) → 1-chloro-4-(2-nitroethyl)benzene (60947-43-5)

Guidance literature:

With formic acid; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; triethylamine; N-tosylethylenediamine; In ethyl acetate; at 28 ℃; for 2h; chemoselective reaction;

DOI:10.1016/j.tet.2012.04.028

Reference yield: 88.0%

1-(4-chlorophenyl)-2-nitroethanol (89979-04-4) → 1-chloro-4-(2-nitroethyl)benzene (60947-43-5)

Guidance literature:

With tri-n-butyl-tin hydride; In water; at 80 ℃; for 0.133333h; Microwave irradiation; Green chemistry;

DOI:10.1080/00397911.2014.926373

Reference yield: 82.0%

1-chloro-4-(2-nitro-1(Z)-ethenyl)benzene (101671-01-6,5153-70-8) → 1-chloro-4-(2-nitroethyl)benzene (60947-43-5)

Guidance literature:

With PBI; In butan-1-ol; for 1h; Heating;

DOI:10.1246/bcsj.60.737

upstream raw materials:

nitromethane

1-(4-chlorobenzyl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate

1-chloro-4-(2-nitrovinyl)benzene

1-nitro-2-(4-chlorophenyl)ethylene

Downstream raw materials:

(4-chlorophenyl)acetaldehyde

1-Chloro-4-(2,2-dichloro-2-nitro-ethyl)-benzene

1,3-bis(4-chlorophenyl)-2-propanamine

1,3-bis(4-chlorophenyl)-2-nitro-1-propene

Refernces

• 1、 Benaglia, Maurizio,Boselli, Monica Fiorenza,Faverio, Chiara,Gonzalez, Patricia Camarero,Puglisi, Alessandra. "Nitroalkene reduction in deep eutectic solvents promoted by BH3NH3". supporting information. p. 1041 - 1047. Retrieved 2021/05/17.
• 2、 Byrne, Andrew J.,Bright, Sandra A.,Fayne, Darren,McKeown, James P.,McCabe, Thomas,Twamley, Brendan,Williams, Clive,Meegan, Mary J.. "Synthesis, antiproliferative and pro-apoptotic effects of nitrostyrenes and related compounds in Burkitt’s lymphoma". . p. 181 - 199. Retrieved 2018/03/13.