Ethyl 4-isopropylpiperazine-1-carboxylate

Base Information

• Chemical Name: Ethyl 4-isopropylpiperazine-1-carboxylate
• CAS No.: 61014-91-3
• Molecular Formula: C10H20N2O2
• Molecular Weight: 200.281
• DSSTox Substance ID: DTXSID90276176
• Wikidata: Q82006552
• Mol file: 61014-91-3.mol

Synonyms:61014-91-3;ETHYL 4-ISOPROPYLPIPERAZINE-1-CARBOXYLATE;Ethyl 4-propan-2-ylpiperazine-1-carboxylate;ETHYL 4-(1-METHYLETHYL)PIPERAZINE-1-CARBOXYLATE;ethyl 4-(propan-2-yl)piperazine-1-carboxylate;SCHEMBL681679;DTXSID90276176;HRMZRPQIFGCXML-UHFFFAOYSA-N;AKOS005216174;ethyl 4-isopropyl-1-piperazinecarboxylate;CS-0454146;ETHYL4-ISOPROPYLPIPERAZINE-1-CARBOXYLATE;Ethyl 4-(1-methylethyl)-1-piperazinylcarboxylate

Chemical Property of Ethyl 4-isopropylpiperazine-1-carboxylate

Chemical Property:

• Vapor Pressure: 0.0113mmHg at 25°C
• Refractive Index: 1.4680
• Boiling Point: 128-130°C 14mm
• Flash Point: 128-130°C/14mm
• Density: 1.028g/cm³
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 200.152477885
• Heavy Atom Count: 14
• Complexity: 187

Purity/Quality:

98%Min ^*data from raw suppliers

ETHYL-4-(1-METHYLETHYL)PIPERAZINE-1-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)N1CCN(CC1)C(C)C

Technology Process of Ethyl 4-isopropylpiperazine-1-carboxylate

There total 5 articles about Ethyl 4-isopropylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-iodo-propane (75-30-9) + 4-ethoxycarbonylpiperazine (120-43-4) → ethyl 4-(1-methylethyl)piperazine-1-carboxylate (61014-91-3)

Guidance literature:

With potassium carbonate; In acetonitrile; for 24h; Heating;

DOI:10.1021/jm981098j

Reference yield:

4-ethoxycarbonylpiperazine (120-43-4) + conc. NH4 OH → ethyl 4-(1-methylethyl)piperazine-1-carboxylate (61014-91-3)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; sodium hydrogencarbonate; In methanol (MeOH); H₂ CCl₂; acetone;

Reference yield:

4-ethoxycarbonylpiperazine (120-43-4) + conc. NH4OH → ethyl 4-(1-methylethyl)piperazine-1-carboxylate (61014-91-3)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; sodium hydrogencarbonate; In H₂CCl₂; methanol (MeOH); acetone;

upstream raw materials:

4-ethoxycarbonylpiperazine

2-iodo-propane

Downstream raw materials:

1-(1-methylethyl)piperazine

2-<4-(1-methylethyl)piperazin-1-yl>ethylamine

(4-isopropyl-piperazin-1-yl)-acetonitrile