1H-Pyrrolo[2,3-b]pyridin-5-amine, 4-fluoro-1-[tris(1-methylethyl)silyl]-

Base Information

Chemical Name:1H-Pyrrolo[2,3-b]pyridin-5-amine, 4-fluoro-1-[tris(1-methylethyl)silyl]-
CAS No.:685513-93-3
Molecular Formula:C16H26FN3Si
Molecular Weight:0
Hs Code.:
Mol file:685513-93-3.mol

Synonyms:1H-Pyrrolo[2,3-b]pyridin-5-amine, 4-fluoro-1-[tris(1-methylethyl)silyl]-

Suppliers and Price of 1H-Pyrrolo[2,3-b]pyridin-5-amine, 4-fluoro-1-[tris(1-methylethyl)silyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
4-FLUORO-1-[TRIS-(1-METHYLETHYL)SILYL]-1H-PYRROLO[2,3-B]PYRIDIN-5-AMINE 95.00%
5MG
$ 503.44

Total 1 raw suppliers

Chemical Property of 1H-Pyrrolo[2,3-b]pyridin-5-amine, 4-fluoro-1-[tris(1-methylethyl)silyl]-

Chemical Property:

Vapor Pressure:8.59E-05mmHg at 25°C
Refractive Index:1.535
Boiling Point:340.5°C at 760 mmHg
Flash Point:159.7°C
PSA：43.84000
Density:1.08g/cm³
LogP:5.36240

Purity/Quality:: 4-FLUORO-1-[TRIS-(1-METHYLETHYL)SILYL]-1H-PYRROLO[2,3-B]PYRIDIN-5-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridin-5-amine, 4-fluoro-1-[tris(1-methylethyl)silyl]-

There total 2 articles about 1H-Pyrrolo[2,3-b]pyridin-5-amine, 4-fluoro-1-[tris(1-methylethyl)silyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 651744-36-4
5-azido-4-fluoro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine

: 685513-93-3
4-fluoro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-5-ylamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 18h; under 760.051 Torr;
DOI:10.1016/j.tetlet.2004.01.122

Reference yield:

: 640735-25-7
4-fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine

: 685513-93-3
4-fluoro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-5-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sec-butyllithium / tetrahydrofuran; cyclohexane / 0.5 h / -78 °C

1.2: 30 percent / tosyl azide / tetrahydrofuran; cyclohexane / 0.42 h / -78 °C

2.1: 100 percent / H₂ / Pd/C / ethyl acetate / 18 h / 20 °C / 760.05 Torr

With hydrogen; sec.-butyllithium; palladium on activated charcoal; In tetrahydrofuran; cyclohexane; ethyl acetate;
DOI:10.1016/j.tetlet.2004.01.122