4-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline

Base Information

Chemical Name:4-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline
CAS No.:607737-87-1
Molecular Formula:C18H14N4
Molecular Weight:286.33
Hs Code.:
DSSTox Substance ID:DTXSID80440480
Nikkaji Number:J2.703.565E
Wikidata:Q82256801
Pharos Ligand ID:RVJQFRCYDU3Y
ChEMBL ID:CHEMBL129677
Mol file:607737-87-1.mol

Synonyms:607737-87-1;A 77-01;4-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline;4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-quinoline;A77-01;4-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline;CHEMBL129677;4-(5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline;4-[3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline;A-77-01;SCHEMBL376179;SCHEMBL17559240;DTXSID80440480;4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quinoline;BCP13726;EX-A2200;BDBM50132989;AKOS015961472;AKOS026750350;CS-1564;NCGC00379015-02;AC-13924;AC-31397;HY-78349;MS-24090;A14436;E98766;3-(6-Methyl-2-pyridyl)-4-(4-quinolinyl)-1H-pyrazole;4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline

Suppliers and Price of 4-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Tocris
A77-01 ≥98%(HPLC)
5
$ 148.00

Tocris
A77-01 ≥98%(HPLC)
25
$ 577.00

DC Chemicals
A77-01 >98%
1 g
$ 1600.00

Crysdot
A77-01 98+%
10mg
$ 126.00

Crysdot
A77-01 98+%
5mg
$ 84.00

ChemScene
A77-01 99.55%
5mg
$ 144.00

ChemScene
A77-01 99.55%
10mg
$ 216.00

Cayman Chemical
A-77-01 ≥98%
25mg
$ 739.00

Cayman Chemical
A-77-01 ≥98%
10mg
$ 338.00

Cayman Chemical
A-77-01 ≥98%
1mg
$ 43.00

Total 13 raw suppliers

Chemical Property of 4-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.685
Boiling Point:481.63°C at 760 mmHg
Flash Point:256.391°C
PSA：54.46000
Density:1.254g/cm³
LogP:3.99530
Solubility.:insoluble in H2O; ≥14.3 mg/mL in DMSO; ≥8.84 mg/mL in EtOH with gentle warming and ultrasonic
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:286.121846464
Heavy Atom Count:22
Complexity:374

Purity/Quality:

99%, ^*data from raw suppliers

A77-01 ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC(=CC=C1)C2=C(C=NN2)C3=CC=NC4=CC=CC=C34

Technology Process of 4-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline

There total 9 articles about 4-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 476472-02-3
1-(6-methylpyridin-2-yl)-2-(quinolin-4-yl)ethan-1-one

: 607737-87-1
4-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline

Guidance literature:: N,N-dimethyl-formamide dimethyl acetal; 1-(6-methylpyridin-2-yl)-2-(quinolin-4-yl)ethan-1-one; With acetic acid; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

With hydrazine hydrate; In N,N-dimethyl-formamide; at 50 ℃; for 1h;

Reference yield:

: (E)-4-Methoxy-1-(6-methyl-pyridin-2-yl)-2-quinolin-4-yl-but-2-en-1-one

: 607737-87-1
4-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline

Guidance literature:: With hydrazine hydrate; In ethanol; for 18h;
DOI:10.1021/jm0205705

Reference yield:

: 491-35-0
C₆H₄NCH₂CHCCH₂

: 607737-87-1
4-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.17 h

1.2: tetrahydrofuran / 18 h

2.1: tetrahydrofuran / 48 h

3.1: hydrazine monohydrate / ethanol / 18 h

With hydrazine hydrate; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol;
DOI:10.1021/jm0205705