1-(6-Methylpyridyl)-2-quinolin-4-yl ethanone

Base Information

Chemical Name:1-(6-Methylpyridyl)-2-quinolin-4-yl ethanone
CAS No.:476472-02-3
Molecular Formula:C₁₇H₁₄N₂O
Molecular Weight:262.311
Hs Code.:
DSSTox Substance ID:DTXSID90473229
Wikidata:Q82302503
Mol file:476472-02-3.mol

Synonyms:476472-02-3;1-(6-Methylpyridyl)-2-quinolin-4-yl ethanone;1-(6-Methylpyridin-2-yl)-2-(quinolin-4-yl)ethanone;1-(6-methylpyridin-2-yl)-2-quinolin-4-ylethanone;SCHEMBL5235225;DTXSID90473229;AKOS014920929;AC-13926

Suppliers and Price of 1-(6-Methylpyridyl)-2-quinolin-4-yl ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-(6-METHYLPYRIDYL)-2-QUINOLIN-4-YL ETHANONE 95.00%
5MG
$ 495.20

Total 4 raw suppliers

Chemical Property of 1-(6-Methylpyridyl)-2-quinolin-4-yl ethanone

Chemical Property:

Vapor Pressure:2.75E-08mmHg at 25°C
Boiling Point:449.9oC at 760 mmHg
Flash Point:225.7oC
PSA：42.85000
Density:1.2g/cm3
LogP:3.36360
XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:262.110613074
Heavy Atom Count:20
Complexity:344

Purity/Quality:

99% ^*data from raw suppliers

1-(6-METHYLPYRIDYL)-2-QUINOLIN-4-YL ETHANONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=NC(=CC=C1)C(=O)CC2=CC=NC3=CC=CC=C23

Technology Process of 1-(6-Methylpyridyl)-2-quinolin-4-yl ethanone

There total 6 articles about 1-(6-Methylpyridyl)-2-quinolin-4-yl ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 4363-93-3
quinoline-4-carboxaldehyde

: 614750-85-5
diphenyl (6-methylpyridin-2-yl)(phenylamino)methylphosphonate

: 476472-02-3
1-(6-methylpyridin-2-yl)-2-(quinolin-4-yl)ethan-1-one

Guidance literature:: With caesium carbonate; In tetrahydrofuran; isopropyl alcohol; at 20 ℃;
DOI:10.1016/j.bmcl.2019.126822

Reference yield: 70.0%

: 491-35-0
C₆H₄NCH₂CHCCH₂

: 39640-51-2
ethyl 6-methylpyridine-2-carboxylate

: 476472-02-3
1-(6-methylpyridin-2-yl)-2-(quinolin-4-yl)ethan-1-one

Guidance literature:: C₆H₄NCH₂CHCCH₂; With sodium hexamethyldisilazane; In tetrahydrofuran; at -60 ℃; Inert atmosphere;

ethyl 6-methylpyridine-2-carboxylate; In tetrahydrofuran; at -60 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2010.05.032

Reference yield:

: 4363-93-3
quinoline-4-carboxaldehyde

: [(6-methyl-pyridyl-2-yl)-phenylamino-methyl]-phosphonic acid diphenyl ester

: 476472-02-3
1-(6-methylpyridin-2-yl)-2-(quinolin-4-yl)ethan-1-one

Guidance literature:: quinoline-4-carboxaldehyde; [(6-methyl-pyridyl-2-yl)-phenylamino-methyl]-phosphonic acid diphenyl ester; With potassium tert-butylate; In tetrahydrofuran; isopropyl alcohol; at 25 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water; isopropyl alcohol; for 1h;

With sodium hydroxide; In tetrahydrofuran; water; isopropyl alcohol; at 45 ℃; pH=5;