Methyl (2-oxopropoxy)acetate

Base Information

• Chemical Name: Methyl (2-oxopropoxy)acetate
• CAS No.: 61363-66-4
• Molecular Formula: C6H10O4
• Molecular Weight: 146.143
• Hs Code.: 2918990090
• European Community (EC) Number: 891-121-5
• ChEMBL ID: CHEMBL4517762
• DSSTox Substance ID: DTXSID20470786
• Nikkaji Number: J2.289.572I
• Wikidata: Q82298959
• Mol file: 61363-66-4.mol

Synonyms:61363-66-4;Methyl 2-(2-oxopropoxy)acetate;methyl (2-oxopropoxy)acetate;(2-OXO-PROPOXY)-ACETIC ACID METHYL ESTER;(2-Oxo-propoxy)-acetic acid methylester;methyl(2-oxopropoxy)acetate;SCHEMBL692344;CHEMBL4517762;DTXSID20470786;NHVGUHQBLOOYQG-UHFFFAOYSA-N;AKOS006288856;(2-oxo-propoxy)acetic acid methyl ester;1-methyl-1'-methoxy-2,2'-oxydiacetaldehyde;CS-0116678;EN300-85904;J-500893

Chemical Property of Methyl (2-oxopropoxy)acetate

Chemical Property:

• Boiling Point: 221.57 °C at 760 mmHg
• Flash Point: 90.6 °C
• PSA: 52.60000
• Density: 1.086 g/cm³
• LogP: -0.23500
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 146.05790880
• Heavy Atom Count: 10
• Complexity: 130

Purity/Quality:

98%Min ^*data from raw suppliers

methyl2-(2-oxopropoxy)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)COCC(=O)OC

Technology Process of Methyl (2-oxopropoxy)acetate

There total 7 articles about Methyl (2-oxopropoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

methyl [(2-methylprop-2-en-1-yl)oxy]acetate (137840-76-7) → (2-oxopropoxy)acetic acid methyl ester (61363-66-4)

Guidance literature:

With potassium osmate(VI); sodium periodate; In tetrahydrofuran; water; at 20 ℃; for 32.5h;

Reference yield: 55.0%

methyl 2-(prop-2-yn-1-yloxy)acetate (67500-49-6) → (2-oxopropoxy)acetic acid methyl ester (61363-66-4)

Guidance literature:

With sulfuric acid; mercury(II) diacetate; In methanol; water; for 0.333333h; Heating;

DOI:10.1081/SCC-120027702

Reference yield:

methyl 2-(prop-2-yn-1-yloxy)acetate (67500-49-6) + mercury(II) diacetate (1600-27-7) → (2-oxopropoxy)acetic acid methyl ester (61363-66-4)

Guidance literature:

With hydrogenchloride; sulfuric acid; In methanol;

upstream raw materials:

2-<(methoxycarbonyl)methoxy>acetyl chloride

methylmagnesium bromide

methyl 2-(prop-2-yn-1-yloxy)acetate

methyl [(2-methylprop-2-en-1-yl)oxy]acetate

Downstream raw materials:

2H-pyran-3,5(4H,6H)-dione

methyl 2-ethyl-4-(4-fluoro-3-iodophenyl)-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridin-3-carboxylate

4-(3-bromo-4-fluoro-phenyl)-2-isobutyl-5-oxo-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylic acid methyl ester

4-(3-bromo-4-fluoro-phenyl)-5-oxo-2-propyl-4,5,6,8-tetrahydro-1H-pyrano[3,4-b]pyridine-3-carboxylic acid methyl ester