Methyl 2-methylthiopropionate

Base Information

• Chemical Name: Methyl 2-methylthiopropionate
• CAS No.: 61366-76-5
• Molecular Formula: C₅H₁₀O₂S
• Molecular Weight: 134.199
• Hs Code.: 2930909090
• Mol file: 61366-76-5.mol

Synonyms:METHYL 2-(METHYLTHIO)PROPIONATE

Chemical Property of Methyl 2-methylthiopropionate

Chemical Property:

• Vapor Pressure: 2.73mmHg at 25°C
• Refractive Index: 1.454
• Boiling Point: 157.6°C at 760 mmHg
• Flash Point: 56.5°C
• PSA: 51.60000
• Density: 1.041g/cm³
• LogP: 0.91090
• Water Solubility.: Immiscible with water.

Purity/Quality:

98.5% ^*data from raw suppliers

Methyl2-(Methylthio)Propionate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 2-Methylthiopropionate is a synthetic flavoring agent that is a colorless liquid of slightly fruity odor with a suggestion of sulfur. it polymerizes slowly and should be stored in glass or tin containers. it is used in pineapple flavors to give the true note of pineapple. it has applications in beverages, ice cream, candy, and baked goods at 0.5–1 ppm. Methyl 2-(methylthio)propionate is used in the contribution of overall aroma perception of the ripe fruit.

Technology Process of Methyl 2-methylthiopropionate

There total 4 articles about Methyl 2-methylthiopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2-(methylthio)propionic acid (58809-73-7) → methyl β-(methylthio)propionate (61366-76-5)

Guidance literature:

In diethyl ether; at 0 ℃;

DOI:10.1021/jo00381a029

Reference yield:

2-mercaptopropanoic acid (79-42-5) → methyl β-(methylthio)propionate (61366-76-5)

Guidance literature:

With aluminum tri-n-butoxide; benzene;

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + (S)-2-(methylthio)propanoic acid (33178-97-1,58809-73-7,80582-20-3) → Methyl-L-(2-methylthio)-propionate (33178-98-2,61366-76-5)

Guidance literature:

DOI:10.1039/j39710002432

upstream raw materials:

diazomethane

2-(methylthio)propionic acid

2-mercaptopropanoic acid

(S)-2-(methylthio)propanoic acid

Downstream raw materials:

(S)-3-methylsulfanyl-pyrrolidine-3-carboxylic acid methyl ester L-tartrate

1-benzyl-3-methylsulfanyl-pyrrolidine-3-carboxylic acid methyl ester

α-methylthio-acrylate de methyle

3-methyl-3-methylthioindol-2-one

Refernces