1-Cyclohexene-1-carbonitrile,3-methyl-3-[(methylthio)methoxy]-(9CI)

Base Information

• Chemical Name: 1-Cyclohexene-1-carbonitrile,3-methyl-3-[(methylthio)methoxy]-(9CI)
• CAS No.: 615265-49-1
• Molecular Formula: C10H15NOS
• Molecular Weight: 197.3
• Mol file: 615265-49-1.mol

Synonyms:1-Cyclohexene-1-carbonitrile,3-methyl-3-[(methylthio)methoxy]-(9CI)

Chemical Property of 1-Cyclohexene-1-carbonitrile,3-methyl-3-[(methylthio)methoxy]-(9CI)

Chemical Property:

• PSA: 58.32000
• LogP: 2.71608

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Cyclohexene-1-carbonitrile,3-methyl-3-[(methylthio)methoxy]-(9CI)

There total 2 articles about 1-Cyclohexene-1-carbonitrile,3-methyl-3-[(methylthio)methoxy]-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

dimethyl sulfoxide (67-68-5,8070-53-9) + 1-(1,1-dimethyl-1-silaethoxy)-3-methylcyclohex-2-ene-1-carbonitrile (615265-46-8) → 3-methyl-3-methylsulfanylmethoxy-cyclohex-1-enecarbonitrile (615265-49-1)

Guidance literature:

dimethyl sulfoxide; With acetic anhydride;

1-(1,1-dimethyl-1-silaethoxy)-3-methylcyclohex-2-ene-1-carbonitrile; at 20 ℃; for 40h;

DOI:10.1021/jo0345291

Reference yield:

3-methylcyclohexen-2-one (1193-18-6) → 3-methyl-3-methylsulfanylmethoxy-cyclohex-1-enecarbonitrile (615265-49-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 95 percent / ZnI₂ / CH₂Cl₂ / 0.67 h / 0 °C

2.1: acetic anhydride

2.2: 55 percent / 40 h / 20 °C

With acetic anhydride; zinc(II) iodide; In dichloromethane;

DOI:10.1021/jo0345291

Reference yield: 92.0%

3-methyl-3-methylsulfanylmethoxy-cyclohex-1-enecarbonitrile (615265-49-1) → 3-hydroxy-3-methylcyclohex-1-ene-1-carbonitrile (450406-20-9)

Guidance literature:

With mercury dichloride; In water; acetonitrile; for 8h;

DOI:10.1021/jo0345291

upstream raw materials:

dimethyl sulfoxide

1-(1,1-dimethyl-1-silaethoxy)-3-methylcyclohex-2-ene-1-carbonitrile

3-methylcyclohexen-2-one

Downstream raw materials:

3-hydroxy-3-methylcyclohex-1-ene-1-carbonitrile

(1SR,5RS,6SR)-5-hydroxy-5-methyl-7-methylidenebicyclo[4.3.0]nonane-1-carbonitrile