Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaS)- (9CI)

Base Information

• Chemical Name: Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaS)- (9CI)
• CAS No.: 692732-03-9
• Molecular Formula: C8H8F2O
• Molecular Weight: 158.1453264
• Hs Code.: 2906290090
• Mol file: 692732-03-9.mol

Synonyms:Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaS)- (9CI)

Chemical Property of Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaS)- (9CI)

Chemical Property:

• PSA: 20.23000
• LogP: 2.01810

Purity/Quality:

99%, ^*data from raw suppliers

(S)-1-(3,5-Difluorophenyl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaS)- (9CI)

There total 9 articles about Benzenemethanol, 3,5-difluoro-alpha-methyl-, (alphaS)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3′,5′-difluoroacetophenone (123577-99-1) → rac-1-(3,5-difluorophenyl)ethan-1-ol (872181-59-4,433228-88-7,692732-03-9,575488-42-5)

Guidance literature:

With methanol; sodium tetrahydroborate; at 20 ℃; for 1.08333h; Inert atmosphere;

Reference yield: 99.0%

3′,5′-difluoroacetophenone (123577-99-1) → (R)-1-(3,5-difluorophenyl)ethan-1-ol (433228-88-7,692732-03-9,575488-42-5)

Guidance literature:

With (2S,3aR,8aS)-ethyl 2-(hydroxydiphenylmethyl)-1,2,3,3a-tetrahydropyrrolo[2,3-b]indole-8(8aH)-carboxylate; dimethyl sulfide borane; In tetrahydrofuran; for 1h; optical yield given as %ee; enantioselective reaction; Reflux; Inert atmosphere;

DOI:10.1002/adsc.200900908

Reference yield: 99.0%

→ (R)-1-(3,5-difluorophenyl)ethan-1-ol (433228-88-7,692732-03-9,575488-42-5)

Guidance literature:

upstream raw materials:

3′,5′-difluoroacetophenone

1-ethyl-3,5-difluorobenzene

3,5-difluorobenzaldehyde

methylmagnesium bromide

Downstream raw materials:

N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide

4-[(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-(trifluoromethyl)piperidin-1-yl]-3-[({6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate

N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-2,3-dihydrofuro[2,3-b]pyridin-5-yl}-6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridine-2-carboxamide

tert-butyl ((3R,4R,5S)-4-{[tert-butyl(dimethyl)silyl]oxy}-1-{5-[({6-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-2,3-dihydrofuro[2,3-b]pyridin-4-yl}-5-methylpiperidin-3-yl)carbamate

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