1H-Indole-2-acetonitrile(9CI)

Base Information

• Chemical Name: 1H-Indole-2-acetonitrile(9CI)
• CAS No.: 7210-27-7
• Molecular Formula: C10H8N2
• Molecular Weight: 156.187
• Mol file: 7210-27-7.mol

Synonyms:1H-Indole-2-acetonitrile(9CI)

Chemical Property of 1H-Indole-2-acetonitrile(9CI)

Chemical Property:

• Boiling Point: 374.1±17.0 °C(Predicted)
• PKA: 16.18±0.30(Predicted)
• PSA: 39.58000
• Density: 1.219±0.06 g/cm3(Predicted)
• LogP: 2.23398
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

2-(Cyanomethyl)indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of carcinogenic indole derivatives.

Technology Process of 1H-Indole-2-acetonitrile(9CI)

There total 1 articles about 1H-Indole-2-acetonitrile(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

indole (120-72-9) + iodoacetonitrile (624-75-9) → 2-indoleacetonitrile (7210-27-7) + indole-3-acetonitrile (771-51-7)

Guidance literature:

With dihydrogen peroxide; iron(II) sulfate; dimethyl sulfoxide; Ambient temperature;

DOI:10.1021/jo00051a027

Reference yield: 95.0%

2-indoleacetonitrile (7210-27-7) + benzaldehyde (100-52-7) → E-2-(1H-indol-2-yl)-3-phenylacrylonitrile

Guidance literature:

With amine functionalized silica coated Fe₃O₄ nanoparticles; In water; at 20 ℃; for 0.333333h; Sonication; Green chemistry;

DOI:10.1016/j.crci.2014.05.012

Reference yield: 93.0%

2-indoleacetonitrile (7210-27-7) + 4-methyl-benzaldehyde (104-87-0) → C18H14N2

Guidance literature:

With amine functionalized silica coated Fe₃O₄ nanoparticles; In water; at 20 ℃; for 0.333333h; Sonication; Green chemistry;

DOI:10.1016/j.crci.2014.05.012

upstream raw materials:

indole

iodoacetonitrile

Downstream raw materials:

1H-indole-2-ethanamine

2-indol-2-ylmethylene-5-phenyl-thiazolidin-4-one

1-Benzyl-5H-pyrido[4,3-b]indol-3-ylamine; compound with acetic acid

1-Propyl-5H-pyrido[4,3-b]indol-3-ylamine; compound with acetic acid

Refernces