clemastine

Base Information

• Chemical Name: clemastine
• CAS No.: 61826-28-6
• Molecular Formula: C₂₁H₂₆ClNO
• Molecular Weight: 343.897
• Mol file: 61826-28-6.mol

Synonyms:Pyrrolidine, 2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-, [S-(R*,S*)]-

Chemical Property of clemastine

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of clemastine

There total 2 articles about clemastine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ MMV637229 (7723-51-5,15686-51-8,61826-27-5,61826-28-6,61826-31-1,63813-90-1,63813-91-2)

Guidance literature:

D-1-Methyl-2-pyrrolidylchloraethan und 1-(p-Chlorphenyl)-1-phenylaethanol unnd NH2Na und Fumarsaeure, 0grad;

Reference yield:

→ 2-{2-[(S)-1-(4-Chloro-phenyl)-1-phenyl-ethoxy]-ethyl}-1-methyl-pyrrolidine (7723-51-5,15686-51-8,61826-27-5,61826-28-6,61826-31-1,63813-90-1,63813-91-2)

Guidance literature:

Racematspaltung von 3-A,B mit (-)-Dibenzoyl-L-weinsaeure;

DOI:10.1002/hlca.19760590721

Reference yield:

propan-1-ol (71-23-8) + Clemastine (7723-51-5,15686-51-8,61826-27-5,61826-28-6,61826-31-1,63813-90-1,63813-91-2) → 2-(1-methyl-2-pyrrolidine)ethanol (67004-64-2) + 1-(4-chloro-phenyl)-1-phenyl-ethanol (59767-24-7) + 1-Phenyl-1-(4-chlorphenyl)-ethylenglycol (28523-14-0) + N-methyl-2-vinylpyrrolidine (85151-07-1) + 4-chlorobenzophenone (134-85-0) + 1-Phenyl-1-(4-chlorphenyl)-1-n-propoxyethan (117932-40-8)

Guidance literature:

With sodium hydroxide; for 53h; Heating; further time and temp.; also without n-propanol, with H₂O or HCl addition;

Downstream raw materials:

2-(1-methyl-2-pyrrolidine)ethanol

1-(4-chloro-phenyl)-1-phenyl-ethanol

1-Phenyl-1-(4-chlorphenyl)-ethylenglycol

N-methyl-2-vinylpyrrolidine