2-Trifluoromethanesulfonyloxyaceticacidethylester

Base Information

• Chemical Name: 2-Trifluoromethanesulfonyloxyaceticacidethylester
• CAS No.: 61836-02-0
• Molecular Formula: C5H7F3O5S
• Molecular Weight: 236.169
• Hs Code.: 2915900090
• Mol file: 61836-02-0.mol

Synonyms:2-Trifluoromethanesulfonyloxyaceticacidethylester

Chemical Property of 2-Trifluoromethanesulfonyloxyaceticacidethylester

Chemical Property:

• PSA: 78.05000
• LogP: 1.49650

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Trifluoromethanesulfonyloxyaceticacidethylester

There total 2 articles about 2-Trifluoromethanesulfonyloxyaceticacidethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

ethyl 2-hydroxyacetate (623-50-7) + trifluoromethylsulfonic anhydride (358-23-6) → ethoxycarbonylmethyl trifluoromethanesulfonate (61836-02-0)

Guidance literature:

With pyridine; In dichloromethane; at -10 - 30 ℃; for 4h; Inert atmosphere;

DOI:10.1002/anie.201916449

Reference yield:

diazoacetic acid ethyl ester (623-73-4) + trifluorormethanesulfonic acid (1493-13-6) → ethoxycarbonylmethyl trifluoromethanesulfonate (61836-02-0)

Guidance literature:

In liquid sulphur dioxide;

DOI:10.1021/jo00439a001 DOI:10.1016/S0040-4039(00)71337-2

Reference yield: 100.0%

ethoxycarbonylmethyl trifluoromethanesulfonate (61836-02-0) + 3-methoxy-2-(2,4,6-trimethylphenyl)-cyclopent-2-en-1-one (84629-38-9) → ethyl 2-[2-methoxy-4-oxo-3-(2,4,6-trimethylphenyl)cyclopent-2-en-1-yl]acetate

Guidance literature:

3-methoxy-2-(2,4,6-trimethylphenyl)-cyclopent-2-en-1-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 0 ℃; for 1.5h; Inert atmosphere;

ethoxycarbonylmethyl trifluoromethanesulfonate; In tetrahydrofuran; at -78 - 0 ℃; for 2h;

upstream raw materials:

diazoacetic acid ethyl ester

trifluorormethanesulfonic acid

ethyl 2-hydroxyacetate

trifluoromethylsulfonic anhydride

Downstream raw materials:

(1-Cyano-cyclohexyl)-dimethylamino-acetic acid ethyl ester

3-Cyano-2-dimethylamino-3-methyl-5-phenyl-pentanoic acid ethyl ester

Methylsulfanyl-((Z)-1-phenyl-pent-1-enyloxy)-acetic acid ethyl ester

Methylsulfanyl-(6-phenyl-cyclohex-1-enyloxy)-acetic acid ethyl ester