Tricyclo[2.2.1.02,6]heptane-1-carboxylic acid, 2,3,3-trimethyl-, methyl ester (9CI)

Base Information

• Chemical Name: Tricyclo[2.2.1.02,6]heptane-1-carboxylic acid, 2,3,3-trimethyl-, methyl ester (9CI)
• CAS No.: 630106-39-7
• Molecular Formula: C12H18O2
• Molecular Weight: 194.27012
• Mol file: 630106-39-7.mol

Synonyms:Tricyclo[2.2.1.02,6]heptane-1-carboxylic acid, 2,3,3-trimethyl-, methyl ester (9CI)

Chemical Property of Tricyclo[2.2.1.02,6]heptane-1-carboxylic acid, 2,3,3-trimethyl-, methyl ester (9CI)

Chemical Property:

• PSA: 26.30000
• LogP: 2.23170

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tricyclo[2.2.1.02,6]heptane-1-carboxylic acid, 2,3,3-trimethyl-, methyl ester (9CI)

There total 4 articles about Tricyclo[2.2.1.02,6]heptane-1-carboxylic acid, 2,3,3-trimethyl-, methyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,4R)-4,7,7-Trimethyl-bicyclo[2.2.1]hept-2-ene-1-carboxylic acid methyl ester (630106-38-6) → methyl 2,7,7-trimethyltricyclo[2.2.1.02,6]heptan-2-carboxylate (630106-39-7)

Guidance literature:

(1R,4R)-4,7,7-Trimethyl-bicyclo[2.2.1]hept-2-ene-1-carboxylic acid methyl ester; With sodium methylate; In methanol; for 48h; Heating;

With toluene-4-sulfonic acid; In hexane; for 21h; Further stages.; Heating;

DOI:10.1039/b309329h

Reference yield:

(1S,6S)-6,9,9-Trimethyl-2-nitroso-2-aza-bicyclo[4.2.1]non-4-en-3-one → methyl 2,7,7-trimethyltricyclo[2.2.1.02,6]heptan-2-carboxylate (630106-39-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaOMe / 1.25 h / 0 °C

2.1: methanol / 1.25 h

2.2: H₂SO₄ / methanol

3.1: NaOMe / methanol / 48 h / Heating

3.2: TsOH / hexane / 21 h / Heating

With sodium methylate; In methanol;

DOI:10.1039/b309329h

Reference yield:

(Z)-3-(3-Diazo-1,2,2-trimethyl-cyclopentyl)-acrylic acid methyl ester → methyl 2,7,7-trimethyltricyclo[2.2.1.02,6]heptan-2-carboxylate (630106-39-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol / 1.25 h

1.2: H₂SO₄ / methanol

2.1: NaOMe / methanol / 48 h / Heating

2.2: TsOH / hexane / 21 h / Heating

With sodium methylate; In methanol;

DOI:10.1039/b309329h

upstream raw materials:

diazomethane

(1R,4R)-4,7,7-Trimethyl-bicyclo[2.2.1]hept-2-ene-1-carboxylic acid methyl ester