3,4-Pyrrolidinediol, 2-[[(5-hydroxypentyl)amino]methyl]-, (2R,3R,4S)- (9CI)

Base Information

Chemical Name:3,4-Pyrrolidinediol, 2-[[(5-hydroxypentyl)amino]methyl]-, (2R,3R,4S)- (9CI)
CAS No.:634583-48-5
Molecular Formula:C₁₀H₂₂N₂O₃
Molecular Weight:218.296
Hs Code.:
Mol file:634583-48-5.mol

Synonyms:3,4-Pyrrolidinediol, 2-[[(5-hydroxypentyl)amino]methyl]-, (2R,3R,4S)- (9CI)

Suppliers and Price of 3,4-Pyrrolidinediol, 2-[[(5-hydroxypentyl)amino]methyl]-, (2R,3R,4S)- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,4-Pyrrolidinediol, 2-[[(5-hydroxypentyl)amino]methyl]-, (2R,3R,4S)- (9CI)

Chemical Property:

Boiling Point:401.8±45.0 °C(Predicted)
PKA:14.26±0.60(Predicted)
PSA：84.75000
Density:1.157±0.06 g/cm3(Predicted)
LogP:-0.84810

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 3,4-Pyrrolidinediol, 2-[[(5-hydroxypentyl)amino]methyl]-, (2R,3R,4S)- (9CI)

There total 3 articles about 3,4-Pyrrolidinediol, 2-[[(5-hydroxypentyl)amino]methyl]-, (2R,3R,4S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 634583-11-2
tert-butyl (3aR,4R,6aS)-tetrahydro-4-{[(5-hydroxypentyl)amino]methyl}-2,2-dimethyl-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate

: 634583-48-5
(2R,3R,4S)-2-{[(5-hydroxypentyl)amino]methyl}pyrrolidine-3,4-diol

Guidance literature:: In water; trifluoroacetic acid; at 20 ℃; for 1h;
DOI:10.1002/hlca.200390153

Reference yield:

: 2508-29-4
5-hydroxypentylamine

: 634583-48-5
(2R,3R,4S)-2-{[(5-hydroxypentyl)amino]methyl}pyrrolidine-3,4-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

2: 100 percent / trifluoroacetic acid; H₂O / 1 h / 20 °C

With sodium tris(acetoxy)borohydride; In water; 1,2-dichloro-ethane; trifluoroacetic acid;
DOI:10.1002/hlca.200390153

Reference yield:

: 117781-13-2
(3aR,4S,6aS)-tert-butyl 4-formyl-2,2-dimethyldihydro-3aH-[1,3]dioxolo[4,5-c]pyrrole-5(4H)-carboxylate

: 634583-48-5
(2R,3R,4S)-2-{[(5-hydroxypentyl)amino]methyl}pyrrolidine-3,4-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

2: 100 percent / trifluoroacetic acid; H₂O / 1 h / 20 °C

With sodium tris(acetoxy)borohydride; In water; 1,2-dichloro-ethane; trifluoroacetic acid;
DOI:10.1002/hlca.200390153