5-(4-METHYLSULFANYL-PHENYL)-1-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 5-(4-METHYLSULFANYL-PHENYL)-1-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 640727-84-0
• Molecular Formula: C18H16 N2 O2 S
• Molecular Weight: 324.403
• Hs Code.: 2933199090
• Mol file: 640727-84-0.mol

Synonyms:Methyl5-(4-methylthiophenyl)-1-phenylpyrazole-3-carboxylate

Chemical Property of 5-(4-METHYLSULFANYL-PHENYL)-1-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• PSA: 69.42000
• LogP: 4.04780

Purity/Quality:

98% ^*data from raw suppliers

5-(4-Methylsulfanyl-phenyl)-1-phenyl-1H-pyrazole-3-carboxylicacidmethylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(4-METHYLSULFANYL-PHENYL)-1-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER

There total 3 articles about 5-(4-METHYLSULFANYL-PHENYL)-1-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

phenylhydrazine hydrochloride (59-88-1) + methyl (2Z)-2-hydroxy-4-(4-methylthiophenyl)-4-oxobut-2-enoate (346684-15-9) → methyl 5-(4-methylthiophenyl)-1-phenylpyrazole-3-carboxylate (640727-84-0)

Guidance literature:

In methanol; at 70 ℃;

DOI:10.1021/jm030276s

Reference yield: 68.0%

→ methyl 5-(4-methylthiophenyl)-1-phenylpyrazole-3-carboxylate (640727-84-0)

Guidance literature:

Reference yield:

4-(Methylthio)acetophenone (1778-09-2) → methyl 5-(4-methylthiophenyl)-1-phenylpyrazole-3-carboxylate (640727-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / sodium methoxide / toluene / 2 h / 20 °C

2: 68 percent / methanol / 70 °C

With sodium methylate; In methanol; toluene;

DOI:10.1021/jm030276s

upstream raw materials:

phenylhydrazine hydrochloride

methyl (2Z)-2-hydroxy-4-(4-methylthiophenyl)-4-oxobut-2-enoate

4-(Methylthio)acetophenone

Downstream raw materials:

N-methoxy-N-methyl(5-(4-methylthiophenyl)-1-phenylpyrazol-3-yl)carboxamide

1-(5-(4-methylthiophenyl)-1-phenylpyrazol-3-yl)-4-(1,1,2,2-tetramethyl-1-silapropoxy)butan-1-one

1-{(3E)-4-[5-(4-methylthiophenyl)-1-phenylpyrazol-3-yl]but-3-enyloxy}-1,1,2,2-tetramethyl-1-silapropane

1-{(3Z)-4-[5-(4-methylthiophenyl)-1-phenylpyrazol-3-yl]but-3-enyloxy}-1,1,2,2-tetramethyl-1-silapropane

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