3-HYDROXY-4-NITRO (1H)INDAZOLE

Base Information

• Chemical Name: 3-HYDROXY-4-NITRO (1H)INDAZOLE
• CAS No.: 7384-16-9
• Molecular Formula: C₇H₅N₃O₃
• Molecular Weight: 179.135
• Hs Code.: 2933990090
• Mol file: 7384-16-9.mol

Synonyms:3-HYDROXY-4-NITRO (1H)INDAZOLE

Chemical Property of 3-HYDROXY-4-NITRO (1H)INDAZOLE

Chemical Property:

• Boiling Point: 309.8±21.0 °C(Predicted)
• PKA: 10.24±0.20(Predicted)
• PSA: 94.73000
• Density: 1.506±0.06 g/cm3(Predicted)
• LogP: 1.69990
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3H-INDAZOL-3-ONE,1,2-DIHYDRO-4-NITRO- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-HYDROXY-4-NITRO (1H)INDAZOLE

There total 2 articles about 3-HYDROXY-4-NITRO (1H)INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

6-nitroanthranilic acid (50573-74-5) → 5-Nitro-3-indazolinon (7384-16-9)

Guidance literature:

6-nitroanthranilic acid; With hydrogenchloride; sodium nitrite; In water; at 20 ℃; for 1h;

With sulfur dioxide; In water; for 1h; Heating / reflux;

Reference yield:

→ 5-Nitro-3-indazolinon (7384-16-9)

Guidance literature:

With hydrogenchloride; sulfur dioxide;

Reference yield: 44.0%

5-Nitro-3-indazolinon (7384-16-9) + methyl iodide (74-88-4) → 4-nitro-1-methyl-1,2-dihydro-indazol-3-one (878156-08-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ISOPROPYLAMIDE; at 20 ℃; for 2h;

upstream raw materials:

6-nitroanthranilic acid

Downstream raw materials:

4-nitro-1-methyl-1,2-dihydro-indazol-3-one

Refernces