Imidazo[1,2-a]pyridine-7-carboxylic acid

Base Information

• Chemical Name: Imidazo[1,2-a]pyridine-7-carboxylic acid
• CAS No.: 648423-85-2
• Molecular Formula: C8H6N2O2
• Molecular Weight: 162.148
• Hs Code.: 2933990090
• European Community (EC) Number: 685-568-3
• DSSTox Substance ID: DTXSID60593145
• Wikidata: Q72482532
• Mol file: 648423-85-2.mol

Synonyms:Imidazo[1,2-a]pyridine-7-carboxylic acid;648423-85-2;MFCD09834781;Imidazo[1,2-a]pyridine-7-carboxylicacid;7-imidazo[1,2-a]pyridinecarboxylic acid;Imidazo[1,2-a]pyridine-7-carboxylic acid (9CI);SCHEMBL557414;DTXSID60593145;TUKDVVKJZVLVTD-UHFFFAOYSA-N;AKOS006344988;HE-0336;PB29686;BP-20226;SY016704;DB-351697;AM20061405;CS-0049334;EN300-102614;A834899;J-521503;Imidazo[1,2-a]pyridine-7-carboxylic acid, AldrichCPR

Chemical Property of Imidazo[1,2-a]pyridine-7-carboxylic acid

Chemical Property:

• Refractive Index: 1.676
• PKA: -0.56±0.41(Predicted)
• PSA: 54.60000
• Density: 1.41 g/cm³
• LogP: 1.03250
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 162.042927438
• Heavy Atom Count: 12
• Complexity: 196

Purity/Quality:

99%, ^*data from raw suppliers

Imidazo[1,2-a]pyridine-7-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN2C=CN=C2C=C1C(=O)O

Technology Process of Imidazo[1,2-a]pyridine-7-carboxylic acid

There total 1 articles about Imidazo[1,2-a]pyridine-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 7-imidazo<1,2-a>pyridinecarboxylate (86718-01-6) → imidazo[1,2-a]pyridine-7-carboxylic acid (648423-85-2)

Guidance literature:

With hydrogenchloride; water; at 50 ℃; for 64h;

Reference yield: 66.0%

imidazo[1,2-a]pyridine-7-carboxylic acid (648423-85-2) + (4-(piperidin-1-ylsulfonyl)phenyl)methanamine (205259-71-8) → N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-7-carboxamide (1362132-28-2)

Guidance literature:

imidazo[1,2-a]pyridine-7-carboxylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 25 ℃; for 0.416667h;

(4-(piperidin-1-ylsulfonyl)phenyl)methanamine; In N,N-dimethyl-formamide; at 25 ℃; for 16h;

DOI:10.1021/jm4008664

Reference yield: 61.0%

imidazo[1,2-a]pyridine-7-carboxylic acid (648423-85-2) + (±)-cis-6-((3-aminocyclohexyl)amino)-2-(5,7-difluoro-1-tosyl-1H-indol-3-yl)-5-fluoro-4-phenylnicotinonitrile → (±)-cis-N-(3-((5-cyano-6-(5,7-difluoro-1-tosyl-1H-indol-3-yl)-3-fluoro-4-phenylpyridin-2-yl)amino)cyclohexyl)imidazo[1,2-a]pyridine-7-carboxamide

Guidance literature:

imidazo[1,2-a]pyridine-7-carboxylic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 0.166667h;

(±)-cis-6-((3-aminocyclohexyl)amino)-2-(5,7-difluoro-1-tosyl-1H-indol-3-yl)-5-fluoro-4-phenylnicotinonitrile; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃;

upstream raw materials:

methyl 7-imidazo<1,2-a>pyridinecarboxylate

Downstream raw materials:

N-{[4-(piperidine-1-sulfonyl)phenyl]methyl}imidazo[1,2-a]pyridine-7-carboxamide

methyl 7-imidazo<1,2-a>pyridinecarboxylate

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