1-Piperazinecarboxamide,N,N,3,5-tetramethyl-,(3R,5S)-(9CI)

Base Information

Chemical Name:1-Piperazinecarboxamide,N,N,3,5-tetramethyl-,(3R,5S)-(9CI)
CAS No.:654071-78-0
Molecular Formula:C₉H₁₉N₃O
Molecular Weight:185.269
Hs Code.:
Mol file:654071-78-0.mol

Synonyms:1-Piperazinecarboxamide,N,N,3,5-tetramethyl-,(3R,5S)-(9CI);(3R,5S)-N,N,3,5-TETRAMETHYLPIPERAZINE-1-CARBOXAMIDE

Suppliers and Price of 1-Piperazinecarboxamide,N,N,3,5-tetramethyl-,(3R,5S)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-Piperazinecarboxamide,N,N,3,5-tetramethyl-,(3R,5S)-(9CI)

Chemical Property:

Boiling Point:287.9±33.0 °C(Predicted)
PKA:8.68±0.60(Predicted)
PSA：35.58000
Density:0.982±0.06 g/cm3(Predicted)
LogP:0.61690

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Piperazinecarboxamide,N,N,3,5-tetramethyl-,(3R,5S)-(9CI)

There total 1 articles about 1-Piperazinecarboxamide,N,N,3,5-tetramethyl-,(3R,5S)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 21655-48-1,1013625-96-1
cis-2,6-dimethylpiperazine

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 654071-78-0
2,6-dimethyl-piperazine-1-carboxylic acid dimethylamide

Guidance literature:: In dichloromethane; for 4h; cooling;
DOI:10.1016/S0968-0896(03)00490-5

Reference yield:

: 654071-78-0
2,6-dimethyl-piperazine-1-carboxylic acid dimethylamide

: C₂₁H₂₆N₈O

Guidance literature:: Multi-step reaction with 3 steps

1.1: POCl₃ / 0.5 h / 110 °C

1.2: 24 percent / acetonitrile / 2 h / Heating

2.1: 48 percent / NaHCO₃ / dimethylformamide / 20 °C

3.1: HCl; ammonium formate / Pd/C / diethyl ether; propan-2-ol

With hydrogenchloride; ammonium formate; sodium hydrogencarbonate; trichlorophosphate; palladium on activated charcoal; In diethyl ether; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/S0968-0896(03)00490-5

Reference yield:

: 654071-78-0
2,6-dimethyl-piperazine-1-carboxylic acid dimethylamide

: (R)-1-{4-[(3S,5R)-4-(4-Cyclopropyl-[1,3,5]triazin-2-yl)-3,5-dimethyl-piperazin-1-yl]-[1,3,5]triazin-2-yl}-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: POCl₃ / 0.5 h / 110 °C

1.2: 24 percent / acetonitrile / 2 h / Heating

2.1: 65 percent / BBr₃ / CH₂Cl₂ / 2 h / cooling

3.1: 98 percent / NaHCO₃ / dimethylformamide / 20 °C

4.1: 64 percent / HCl; ammonium formate / Pd/C / diethyl ether; propan-2-ol / 2 h / 90 °C

With hydrogenchloride; ammonium formate; boron tribromide; sodium hydrogencarbonate; trichlorophosphate; palladium on activated charcoal; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/S0968-0896(03)00490-5