1-(4-METHYL-2-PHENYL-1,3-THIAZOL-5-YL)ETHAN-1-ONE

Base Information

• Chemical Name: 1-(4-METHYL-2-PHENYL-1,3-THIAZOL-5-YL)ETHAN-1-ONE
• CAS No.: 7520-94-7
• Molecular Formula: C12H11NOS
• Molecular Weight: 217.291
• Hs Code.: 2934100090
• Mol file: 7520-94-7.mol

Synonyms:1-(4-METHYL-2-PHENYL-1,3-THIAZOL-5-YL)ETHAN-1-ONE;1-(4-METHYL-2-PHENYL-1,3-THIAZOL-5-YL)-1-ETHANONE

Chemical Property of 1-(4-METHYL-2-PHENYL-1,3-THIAZOL-5-YL)ETHAN-1-ONE

Chemical Property:

• Vapor Pressure: 1.43E-05mmHg at 25°C
• Melting Point: 67 °C
• Refractive Index: 1.586
• Boiling Point: 366.8°C at 760 mmHg
• Flash Point: 175.6°C
• PSA: 58.20000
• Density: 1.173g/cm³
• LogP: 3.32110

Purity/Quality:

98%Min ^*data from raw suppliers

1-(4-methyl-2-phenyl-1,3-thiazol-5-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-METHYL-2-PHENYL-1,3-THIAZOL-5-YL)ETHAN-1-ONE

There total 18 articles about 1-(4-METHYL-2-PHENYL-1,3-THIAZOL-5-YL)ETHAN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-chloropentane-2,4-dione (1694-29-7) + benzenecarbothioamide (2227-79-4) → 5-acetyl-4-methyl-2-phenylthiazole (7520-94-7)

Guidance literature:

In ethanol; for 8h;

DOI:10.1016/j.ejmech.2020.113125

Reference yield: 85.0%

2,4-dioxopentan-3-yl 4-methylbenzenesulfonate (81447-35-0) + benzenecarbothioamide (2227-79-4) → 5-acetyl-4-methyl-2-phenylthiazole (7520-94-7)

Guidance literature:

In water; at 60 ℃; for 5h;

DOI:10.1016/j.tetlet.2011.02.069

Reference yield: 85.0%

<1-Hydroxy-1-(4-methyl-2-phenyl-5-thiazolyl)ethyl>phosphonsaeure-diethylester (100288-98-0) → 5-acetyl-4-methyl-2-phenylthiazole (7520-94-7)

Guidance literature:

With sodium hydroxide; for 5h; Ambient temperature;

upstream raw materials:

2-diazo-1-(4-methyl-2-phenyl-thiazol-5-yl)-ethanone

3-chloropentane-2,4-dione

benzenecarbothioamide

phenylthioamide

Downstream raw materials:

1-[4-methyl-2-(4-nitro-phenyl)-thiazol-5-yl]-ethanone

2,2-Dimethoxy-2-(4-methyl-2-phenyl-thiazol-5-yl)-ethanol

2-bromo-1-(4-methyl-2-phenyl-1,3-thiazol-5-yl)-1-ethanone

Methyl 4-Bromomethyl-2-phenyl-5-thiazolyl Ketone