Quinazoline, 8-methyl- (7CI,8CI,9CI)

Base Information

• Chemical Name: Quinazoline, 8-methyl- (7CI,8CI,9CI)
• CAS No.: 7557-03-1
• Molecular Formula: C9H8N2
• Molecular Weight: 144.17322
• Mol file: 7557-03-1.mol

Synonyms:Quinazoline, 8-methyl- (7CI,8CI,9CI)

Chemical Property of Quinazoline, 8-methyl- (7CI,8CI,9CI)

Chemical Property:

• PSA: 25.78000
• LogP: 1.93820
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

8-Methylquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Quinazoline, 8-methyl- (7CI,8CI,9CI)

There total 4 articles about Quinazoline, 8-methyl- (7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4-chloro-8-methylquinazoline (58421-80-0) → 8-methylquinazoline (7557-03-1)

Guidance literature:

With toluene-4-sulfonic acid hydrazide; In dichloromethane; at 45 ℃; for 12h; Inert atmosphere;

Reference yield:

3-methylantranilic acid (4389-45-1) → 8-methylquinazoline (7557-03-1)

Guidance literature:

Multi-step reaction with 3 steps

1: formamidine acetic acid / 16 h / 160 °C

2: trichlorophosphate / 12 h / 120 °C / Inert atmosphere

3: toluene-4-sulfonic acid hydrazide / dichloromethane / 12 h / 45 °C / Inert atmosphere

With formamidine acetic acid; toluene-4-sulfonic acid hydrazide; trichlorophosphate; In dichloromethane;

Reference yield:

8-methylquinazolin-4(3H)-one (19181-54-5) → 8-methylquinazoline (7557-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 12 h / 120 °C / Inert atmosphere

2: toluene-4-sulfonic acid hydrazide / dichloromethane / 12 h / 45 °C / Inert atmosphere

With toluene-4-sulfonic acid hydrazide; trichlorophosphate; In dichloromethane;

upstream raw materials:

3-methylantranilic acid

8-methylquinazolin-4(3H)-one

4-chloro-8-methylquinazoline

Downstream raw materials:

5-bromoquinazoline-8-carbonitrile

N-[(S)-2-(8-cyano-quinazolin-5-ylamino)-2-(3-fluoro-phenyl)-ethyl]-N-methyl-4-nitro-benzenesulfonamide

(S)-5-((1-(3-fluorophenyl)-2-(methylamino)ethyl)amino)quinazoline-8-carboxamide