2-Amino-4-morpholino-6-methylpyrimidine

Base Information

• Chemical Name: 2-Amino-4-morpholino-6-methylpyrimidine
• CAS No.: 7752-46-7
• Molecular Formula: C9H14N4O
• Molecular Weight: 194.236
• DSSTox Substance ID: DTXSID30394585
• Wikidata: Q82194059
• ChEMBL ID: CHEMBL1883812
• Mol file: 7752-46-7.mol

Synonyms:2-Amino-4-morpholino-6-methylpyrimidine;7752-46-7;4-Methyl-6-morpholinopyrimidin-2-amine;4-methyl-6-morpholin-4-ylpyrimidin-2-amine;4-methyl-6-morpholino-2-pyrimidinamine;MLS000720750;SMR000336746;4-methyl-6-(morpholin-4-yl)pyrimidin-2-amine;Oprea1_676756;SCHEMBL5789932;CHEMBL1883812;BDBM90552;cid_3642905;DTXSID30394585;HMS2729C12;MFCD00464137;STK366503;AKOS005443293;CS-0366619;FT-0636588;(4-methyl-6-morpholino-pyrimidin-2-yl)amine;4-methyl-6-(4-morpholinyl)-2-pyrimidinamine;4-methyl-6-morpholin-4-yl-pyrimidin-2-amine;5X-0803;A839125

Chemical Property of 2-Amino-4-morpholino-6-methylpyrimidine

Chemical Property:

• Vapor Pressure: 2.38E-08mmHg at 25°C
• Refractive Index: 1.59
• Boiling Point: 451.7 °C at 760 mmHg
• Flash Point: 227 °C
• PSA: 64.27000
• Density: 1.231 g/cm³
• LogP: 0.85000
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 194.11676108
• Heavy Atom Count: 14
• Complexity: 184

Purity/Quality:

98%min ^*data from raw suppliers

4-METHYL-6-MORPHOLINO-2-PYRIMIDINAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC(=N1)N)N2CCOCC2

Technology Process of 2-Amino-4-morpholino-6-methylpyrimidine

There total 3 articles about 2-Amino-4-morpholino-6-methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

morpholine (110-91-8,99108-56-2) + 2-amino-6-methyl-4-chloropyrimidine (5600-21-5) → 2-amino-4-methyl-6-morpholinopyrimidine (7752-46-7)

Guidance literature:

In water; at 110 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1002/ejoc.201800594

Reference yield:

2-amino-6-methylpyrimidin-4-ol (3977-29-5) → 2-amino-4-methyl-6-morpholinopyrimidine (7752-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 2 h / Reflux

2: water / 0.33 h / 110 °C / Microwave irradiation

With trichlorophosphate; In water;

DOI:10.1002/ejoc.201800594

Reference yield:

morpholine (110-91-8,99108-56-2) + 2-amino-6-methyl-4-chloropyrimidine (5600-21-5) + water (7732-18-5) → 2-amino-4-methyl-6-morpholinopyrimidine (7752-46-7)

Guidance literature:

Rate constant; Abhaengigkeit dieser Reaktion von der Aciditaet der Loesung;

DOI:10.1021/jo01143a003

upstream raw materials:

morpholine

2-amino-6-methyl-4-chloropyrimidine

water

2-amino-6-methylpyrimidin-4-ol

Downstream raw materials:

2-hydroxy-6-methyl-8-morpholin-4-yl-4H-pyrimido[1,2-a]pyrimidin-4-one

Refernces