1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 63430-79-5
• Molecular Formula: C11H13NO2
• Molecular Weight: 191.23
• Hs Code.: 2915900090
• Mol file: 63430-79-5.mol

Synonyms:1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLIC ACID METHYL ESTER;AKOS BBS-00001383

Chemical Property of 1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• PSA: 38.33000
• LogP: 1.72430

Purity/Quality:

97% ^*data from raw suppliers

1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLIC ACID METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLIC ACID METHYL ESTER

There total 25 articles about 1,2,3,4-TETRAHYDRO-QUINOLINE-2-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

quinoline-2-carboxylic acid methyl ester (19575-07-6) → 1,2,3,4-tetrahydro-quinoline-2-carboxylic acid methyl ester (63430-79-5)

Guidance literature:

With platinum(IV) oxide; hydrogen; In methanol; under 45004.5 - 52505.3 Torr;

DOI:10.1002/anie.201007673

Reference yield: 98.0%

methyl 4-(2-aminophenyl)-2-diazobutanoate → 1,2,3,4-tetrahydro-quinoline-2-carboxylic acid methyl ester (63430-79-5)

Guidance literature:

With (S,S)-2,2'-isopropylidenebis(4-phenyl-2-oxazoline); sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; copper dichloride; In dichloromethane; at 25 ℃; for 0.0833333h; Reagent/catalyst; Solvent; Schlenk technique;

DOI:10.1002/adsc.201600390

Reference yield: 85.0%

1,2,3,4-tetrahydroquinoline-2-carboxylic acid methyl ester hydrochloride (78348-26-2) → 1,2,3,4-tetrahydro-quinoline-2-carboxylic acid methyl ester (63430-79-5)

Guidance literature:

With sodium hydroxide; In water; ethyl acetate; for 1h; Large scale;

DOI:10.1021/acs.oprd.9b00364

upstream raw materials:

quinoline-2-carboxylic acid methyl ester

methanol

1,2,3,4-tetrahydroquinoline-2-carboxylic acid

quinoline-2-carboxylic acid

Downstream raw materials:

methyl (2S)-1,2,3,4-tetrahydroquinoline-2-carboxylate

(2R)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid

methyl N-benzoyl-1,2,3,4-tetrahydroquinoline-2-carboxylate

methyl 1-phenyl-1,2,3,4-tetrahydroquinoline-2-carboxylate