2-(3-BROMO-1-METHYL-2-OXOPROPYL)-L H-ISINDOLE-1,3-(2H)-DIONE

Base Information

• Chemical Name: 2-(3-BROMO-1-METHYL-2-OXOPROPYL)-L H-ISINDOLE-1,3-(2H)-DIONE
• CAS No.: 70386-38-8
• Molecular Formula: C12H10BrNO3
• Molecular Weight: 296.12
• Mol file: 70386-38-8.mol

Synonyms:2-(3-BROMO-1-METHYL-2-OXOPROPYL)-L H-ISINDOLE-1,3-(2H)-DIONE;2-(3-Bromo-1-methyl-2-oxopropyl)-1H-isoindole-1,3-(2H)-dione;N-(3-Bromo-1-methyl-2-oxopropyl)phthalimide

Chemical Property of 2-(3-BROMO-1-METHYL-2-OXOPROPYL)-L H-ISINDOLE-1,3-(2H)-DIONE

Chemical Property:

• PSA: 54.45000
• LogP: 1.57300

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-BROMO-1-METHYL-2-OXOPROPYL)-L H-ISINDOLE-1,3-(2H)-DIONE

There total 11 articles about 2-(3-BROMO-1-METHYL-2-OXOPROPYL)-L H-ISINDOLE-1,3-(2H)-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(1-methyl-2-oxo-propyl)-isoindole-1,3-dione (2028-33-3) → D,L-1-bromo-3-phthalimido-2-butanone (70386-38-8)

Guidance literature:

With bromine; In water; acetic acid; at 20 ℃;

DOI:10.1248/cpb.58.208

Reference yield:

1-diazo-3-phthalimido-2-butanone (77202-58-5) → D,L-1-bromo-3-phthalimido-2-butanone (70386-38-8)

Guidance literature:

With hydrogen bromide; In diethyl ether; water; at 0 - 20 ℃; for 0.833333h;

DOI:10.1248/cpb.59.991

Reference yield:

2-phthalimidopropionic acid (21860-84-4) → D,L-1-bromo-3-phthalimido-2-butanone (70386-38-8)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂

2: 2) HBr

With thionyl chloride; hydrogen bromide;

DOI:10.1007/BF00959578

upstream raw materials:

diazomethane

2-(1,3-dioxoisoindolin-2-yl)propanoyl chloride

phthalic anhydride

2-phthalimidopropionic acid

Downstream raw materials:

2-{3-[(4-Methoxy-phenyl)-methyl-amino]-1-methyl-2-oxo-propyl}-isoindole-1,3-dione

C₁₉H₁₅ClN₄O₂S

C₂₀H₁₈N₄O₂S

C₂₀H₁₇ClN₄O₂S