4-Chloro-2-fluorophenylhydrazine hydrochloride

Base Information

• Chemical Name: 4-Chloro-2-fluorophenylhydrazine hydrochloride
• CAS No.: 64172-78-7
• Molecular Formula: C₆H₆ClFN₂*ClH
• Molecular Weight: 197.039
• Hs Code.: 2928000090
• European Community (EC) Number: 812-743-5
• DSSTox Substance ID: DTXSID60382359
• Mol file: 64172-78-7.mol

Synonyms:64172-78-7;4-Chloro-2-fluorophenylhydrazine hydrochloride;(4-chloro-2-fluorophenyl)hydrazine hydrochloride;4-Chloro-2-fluorophenylhydrazine HCl;4-Chloro-2-fluorophenylhydrazine HCl;4-Chloro-2-fluorophenylhydrazine, HCl;(4-chloro-2-fluorophenyl)hydrazine;hydrochloride;MFCD06245512;Hydrazine, (4-chloro-2-fluorophenyl)-, monohydrochloride;SCHEMBL2173110;DTXSID60382359;HPKBNVJFGMBBFK-UHFFFAOYSA-N;AKOS015845809;GS-3526;SY012026;Tert-Butyl(R)-2-oxopiperidin-3-ylcarbamate;4-chloro-2fluorophenylhydrazine hydrochloride;CS-0030583;FT-0677335;(4-chloro-2-fluorophenyl)-hydrazine HCl salt;(4-chloro-2-fluorophenyl)hydrazinehydrochloride;4-Chloro-2-fluorophenyl hydrazine hydrochloride;A21616;EN300-650550;1-(4-chloro-2-fluorophenyl)hydrazine hydrochloride;(4-Chloro-2-fluoro-phenyl)-hydrazine hydrochloride;(4-Chloro-2-fluorophenyl)hydrazine hydrochloride

Chemical Property of 4-Chloro-2-fluorophenylhydrazine hydrochloride

Chemical Property:

• Vapor Pressure: 0.087mmHg at 25°C
• Melting Point: 234-235°C
• Refractive Index: 1.624
• Boiling Point: 225.3°C at 760 mmHg
• Flash Point: 90.1°C
• PSA: 38.05000
• Density: 1.43g/cm³
• LogP: 3.34000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 195.9970318
• Heavy Atom Count: 11
• Complexity: 112

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-2-fluorophenylhydrazinehydrochloride ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)F)NN.Cl
• Uses: 4-Chloro-2-fluorophenylhydrazine, HCl

Technology Process of 4-Chloro-2-fluorophenylhydrazine hydrochloride

There total 1 articles about 4-Chloro-2-fluorophenylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-(4-chloro-2-fluorophenyl)hydrazine hydrochloride (64172-78-7)

Guidance literature:

Reference yield: 20.0%

2-(4-chloro-2-fluorophenyl)hydrazine hydrochloride (64172-78-7) + C9H13N + 4-chlorobenzenesulfonyl chloride (98-60-2) → 4-chloro-N-{2-[5-chloro-7-fluoro-2-(pent-4-yn-1-yl)-1H-indol-3-yl]ethyl}benzene-1-sulfonamide (1604799-83-8)

Guidance literature:

4-chlorobenzenesulfonyl chloride; With dmap; In N,N-dimethyl-formamide; at 0 - 23 ℃; for 0.5h;

C₉H₁₃N; In N,N-dimethyl-formamide; at 23 ℃; for 0.5h;

2-(4-chloro-2-fluorophenyl)hydrazine hydrochloride; Further stages;

DOI:10.1021/jm500146g

Reference yield:

2-(4-chloro-2-fluorophenyl)hydrazine hydrochloride (64172-78-7) → 4-chloro-N-[2-(4aS,9aS)-(6-chloro-8-fluoro-4-methylidene-2,3,4,4a,9,9a-hexahydro-1H-carbazol-4a-yl)ethyl]benzene-1-sulfonamide

Guidance literature:

Multi-step reaction with 3 steps

1.1: dmap / N,N-dimethyl-formamide / 0.5 h / 0 - 23 °C

1.2: 0.5 h / 23 °C

2.1: [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold (I) / toluene / 50 °C / Inert atmosphere

3.1: acetic acid; sodium cyanoborohydride / methanol / 0.5 h / 0 - 23 °C

With dmap; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold (I); sodium cyanoborohydride; acetic acid; In methanol; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm500146g

Downstream raw materials:

C₁₆H₁₆FN₃O₂S₂

4-chloro-N-{2-[5-chloro-7-fluoro-2-(pent-4-yn-1-yl)-1H-indol-3-yl]ethyl}benzene-1-sulfonamide

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