2-[(PHENYLAMINO)METHYL]PHENOL

Base Information

• Chemical Name: 2-[(PHENYLAMINO)METHYL]PHENOL
• CAS No.: 3526-45-2
• Molecular Formula: C13H13 N O
• Molecular Weight: 199.252
• Hs Code.: 2922299090
• Mol file: 3526-45-2.mol

Synonyms:o-Cresol, a-anilino- (6CI,7CI,8CI);2-(Anilinomethyl)phenol; 2-[(Phenylamino)methyl]phenol;N-(2-Hydroxybenzyl)aniline; N-Phenyl-2-hydroxybenzylamine;N-Phenylsalicylamine; NSC 119547; NSC 4111; Salicyl aniline;o-(Anilinomethyl)phenol

Chemical Property of 2-[(PHENYLAMINO)METHYL]PHENOL

Chemical Property:

• Vapor Pressure: 1.14E-05mmHg at 25°C
• Boiling Point: 359.5°C at 760 mmHg
• Flash Point: 151.6°C
• PSA: 32.26000
• Density: 1.185g/cm³
• LogP: 3.07730

Purity/Quality:

98%min ^*data from raw suppliers

2-(Anilinomethyl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(PHENYLAMINO)METHYL]PHENOL

There total 50 articles about 2-[(PHENYLAMINO)METHYL]PHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

salicylaldehyde (90-02-8) + aniline (62-53-3) → 2-((phenylamino)methyl)phenol (3526-45-2)

Guidance literature:

With Bu₂SnClH-HMPA; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1055/s-1998-1895

Reference yield: 99.0%

2-methyl-benzyl alcohol (89-95-2) + aniline (62-53-3) → 2-((phenylamino)methyl)phenol (3526-45-2)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; dibutyltin chloride; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1055/s-2000-6273

Reference yield: 98.0%

salicylidene aniline (779-84-0,103886-91-5,103886-92-6) → 2-((phenylamino)methyl)phenol (3526-45-2)

Guidance literature:

With phenylsilane; (1-(3-methoxybenzyl)-3-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-ylidene)p-cymeneruthenium(II) chloride; In ethanol; at 30 ℃; for 0.0833333h; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/ejic.202000069

upstream raw materials:

tetrachloromethane

diphenyl oxalate

N,N'-diphenylmethylenediamine

N-phenylsalicylaldimine

Downstream raw materials:

2,10-Diphenyl-9,10-dihydro-4-oxa-2,10-diaza-benzo[f]azulene-1,3-dione

N-(4'-I-phenyl)-o-hydroxybenzylamine

ortho-cresol

aniline

Refernces

• 1、 Ganguli, Ashok K.,Kaur, Manpreet,Kaur, Navneet,Mishra, Jayanti. "Highly selective and sensitive simultaneous nanomolar detection of Cs(i) and Al(iii) ions using tripodal organic nanoparticles in aqueous media: The effect of the urea backbone on chemosensing". . p. 22691 - 22700. Retrieved 2020.
• 2、 Kathuria, Lakshay,Samuelson, Ashoka G.. "Chiral N-heterocyclic carbene-iridium complexes for asymmetric reduction of prochiral ketimines". supporting information. . Retrieved 2020/12/28.
• 3、 Fan, Qing-Hua,Liu, Xintong,Luo, Zhenli,Pan, Yixiao,Xu, Lijin,Yang, Ji,Yao, Zhen,Zhang, Xin. "BF3·Et2O as a metal-free catalyst for direct reductive amination of aldehydes with amines using formic acid as a reductant". supporting information. p. 5205 - 5211. Retrieved 2021/07/29.