2-Chloro-6-(trifluoromethyl)pyridin-4-amine

Base Information

Chemical Name:2-Chloro-6-(trifluoromethyl)pyridin-4-amine
CAS No.:34486-22-1
Molecular Formula:C6H4ClF3N2
Molecular Weight:196.559
Hs Code.:2933399090
DSSTox Substance ID:DTXSID80558392
Wikidata:Q72435026
Mol file:34486-22-1.mol

Synonyms:34486-22-1;2-Chloro-6-(trifluoromethyl)pyridin-4-amine;4-Amino-2-chloro-6-(trifluoromethyl)pyridine;2-Chloro-6-trifluoromethyl-pyridin-4-ylamine;MFCD12828259;4-Pyridinamine, 2-chloro-6-(trifluoromethyl)-;SCHEMBL8058901;DTXSID80558392;MXOHYUGYDQGRGI-UHFFFAOYSA-N;AKOS005063703;AB66373;AS-50932;SY097623;4-Amino-2-chloro-6-trifluoromethylpyridine;2-chloro-6-(trifluoromethyl)-4-pyridinamine;2-Chloro-6-trifluoromethylpyridin-4-ylamine;CS-0051937;2-Chloro-6-trifluoromethyl-pyridin-6-ylamine;4-Pyridinamine,2-chloro-6-(trifluoromethyl)-;2-chloranyl-6-(trifluoromethyl)pyridin-4-amine;P11503;A822253;J-508918

Suppliers and Price of 2-Chloro-6-(trifluoromethyl)pyridin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Chloro-6-(trifluoromethyl)pyridin-4-amine
50mg
$ 45.00

TRC
2-Chloro-6-(trifluoromethyl)pyridin-4-amine
500mg
$ 110.00

J&W Pharmlab
2-Chloro-6-trifluoromethyl-pyridin-4-ylamine 96%
1g
$ 67.00

Crysdot
2-Chloro-6-(trifluoromethyl)pyridin-4-amine 95+%
10g
$ 450.00

Crysdot
2-Chloro-6-(trifluoromethyl)pyridin-4-amine 95+%
5g
$ 250.00

Chemenu
4-Amino-2-chloro-6-(trifluoromethyl)pyridine 95%
25g
$ 299.00

Ambeed
2-Chloro-6-(trifluoromethyl)pyridin-4-amine 96%
10g
$ 459.00

Ambeed
2-Chloro-6-(trifluoromethyl)pyridin-4-amine 96%
25g
$ 821.00

Ambeed
2-Chloro-6-(trifluoromethyl)pyridin-4-amine 96%
1g
$ 54.00

Ambeed
2-Chloro-6-(trifluoromethyl)pyridin-4-amine 96%
250mg
$ 35.00

Total 36 raw suppliers

Chemical Property of 2-Chloro-6-(trifluoromethyl)pyridin-4-amine

Chemical Property:

Vapor Pressure:0.0118mmHg at 25°C
Refractive Index:1.501
Boiling Point:261 °C at 760 mmHg
PKA:0.30±0.50(Predicted)
Flash Point:111.7 °C
PSA：38.91000
Density:1.507 g/cm³
LogP:2.91720
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:196.0015103
Heavy Atom Count:12
Complexity:161

Purity/Quality:

98% ^*data from raw suppliers

2-Chloro-6-(trifluoromethyl)pyridin-4-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C=C(N=C1C(F)(F)F)Cl)N

Technology Process of 2-Chloro-6-(trifluoromethyl)pyridin-4-amine

There total 1 articles about 2-Chloro-6-(trifluoromethyl)pyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34486-22-1
4-amino-2-chloro-6-(trifluoromethyl)pyridine

Guidance literature:: entspr. 2,4-Dichlorverb., NH3;

Reference yield: 33.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 34486-22-1
4-amino-2-chloro-6-(trifluoromethyl)pyridine

: 1373223-18-7
tert-butyl (2-chloro-6-(trifluoromethyl)pyridin-4-yl)carbamate

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 25 ℃; for 16h;

Reference yield:

: 34486-22-1
4-amino-2-chloro-6-(trifluoromethyl)pyridine

: N-[1-(3,5-difluorophenyl)-1,2,4-triazol-3-yl]-2-(3-methoxypropoxy)-6-(trifluoromethyl)pyridin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / 1,4-dioxane / 1 h / 20 °C

1.2: 110 °C

2.1: [2-(di-tert-butylphosphino)-2′,4′,6′-triisopropyl-1,1′-biphenyl][2-((2-aminoethyl)phenyl)]palladium(II) chloride; sodium t-butanolate / tert-butyl alcohol / 0.33 h / 90 °C

With [2-(di-tert-butylphosphino)-2′,4′,6′-triisopropyl-1,1′-biphenyl][2-((2-aminoethyl)phenyl)]palladium(II) chloride; sodium hydride; sodium t-butanolate; In 1,4-dioxane; tert-butyl alcohol; 2.1: |Buchwald-Hartwig Coupling;