6-bromopyridine-2-sulfonyl chloride

Base Information

• Chemical Name: 6-bromopyridine-2-sulfonyl chloride
• CAS No.: 912934-77-1
• Molecular Formula: C5H3BrClNO2S
• Molecular Weight: 256.507
• Mol file: 912934-77-1.mol

Synonyms:6-bromopyridine-2-sulfonyl chloride

Chemical Property of 6-bromopyridine-2-sulfonyl chloride

Chemical Property:

• Vapor Pressure: 9.55E-05mmHg at 25°C
• Refractive Index: 1.593
• Boiling Point: 349.3 °C at 760 mmHg
• Flash Point: 165.1 °C
• PSA: 55.41000
• Density: 1.893g/cm³
• LogP: 2.85240
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99%, ^*data from raw suppliers

6-BROMOPYRIDINE-2-SULFONYLCHLORIDE 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-bromopyridine-2-sulfonyl chloride

There total 3 articles about 6-bromopyridine-2-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-Dibromopyridine (626-05-1) → 2-bromo-6-chloro-pyridine (5140-72-7) + 6-bromopyridine-2-sulfonyl chloride (912934-77-1)

Guidance literature:

2,6-Dibromopyridine; With n-butyllithium; dibutylmagnesium; In tetrahydrofuran; at -11 - -10 ℃; for 2.66667h; Inert atmosphere; Large scale reaction;

With sulfuryl dichloride; In tetrahydrofuran; toluene; at -12 ℃; for 1.58333h; Large scale reaction;

DOI:10.1055/s-0030-1259953

Reference yield:

2,6-Dibromopyridine (626-05-1) → 6-bromopyridine-2-sulfonyl chloride (912934-77-1)

Guidance literature:

2,6-Dibromopyridine; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 0.5h;

With sulfur dioxide; In tetrahydrofuran; at -40 ℃; for 0.5h;

With sulfuryl dichloride; In tetrahydrofuran; at -40 - 20 ℃;

DOI:10.1021/jo034643j

Reference yield:

2-benzylsulphenyl-6-bromopyridine (93681-52-8) → 6-bromopyridine-2-sulfonyl chloride (912934-77-1)

Guidance literature:

With chlorine; In tetrachloromethane; water; for 0.333333h; Cooling with ice;

DOI:10.1021/acs.jmedchem.6b01889

upstream raw materials:

2,6-Dibromopyridine

2-benzylsulphenyl-6-bromopyridine

Downstream raw materials:

6-bromopyridine-2-sulfonamide

C⁽³⁷²⁾H₅₁₉₁

6-[3-(3-chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]pyridine-2-sulfonic acid amide

C₂₇H₂₇N₃O₃S

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