ETHYL 1-BENZYL-HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 1-BENZYL-HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE
• CAS No.: 894853-99-7
• Molecular Formula: C₁₆H₂₂N₂O₂
• Molecular Weight: 274.363
• Mol file: 894853-99-7.mol

Synonyms:Pyrrolo[3,?4-?b]?pyrrole-?5(1H)?-?carboxylic acid, hexahydro-?1-?(phenylmethyl)?-?, ethyl ester, (3aR,?6aR)?-?rel-;

Chemical Property of ETHYL 1-BENZYL-HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE

Chemical Property:

• PSA: 32.78000
• LogP: 2.22500

Purity/Quality:

97% ^*data from raw suppliers

cis-1-Benzyl-5-ethoxycarbonylhexahydropyrrolo[3,4-b]pyrrole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: cis-1-Benzyl-5-ethoxycarbonylhexahydropyrrolo[3,4-b]pyrrole is used as a reactant in the stereoselective preparation of racemic pyrimidinyldiazabicyclo[3.3.0]octanes as selective 5-HT2C receptor agonists.

Technology Process of ETHYL 1-BENZYL-HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE

There total 6 articles about ETHYL 1-BENZYL-HEXAHYDROPYRROLO[3,4-B]PYRROLE-5(1H)-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Gly-OBz (1738-68-7) + N-allyl-N-(2-oxoethyl)carbamic acid,ethyl ester (128740-03-4) → ethyl 1-benzyl-octahydropyrrolo[2,3-c]pyrrole-5-carboxylate (132414-78-9,894853-99-7)

Guidance literature:

In toluene; for 4h; Reflux;

Reference yield:

ethyl N-allyl-N-(2-oxoethyl)-carbamidate + N-benzylglycine (17136-36-6) → ethyl 1-benzyl-octahydropyrrolo[2,3-c]pyrrole-5-carboxylate (132414-78-9,894853-99-7)

Guidance literature:

In toluene;

Reference yield:

N-benzylglycine (17136-36-6) + N-allyl-N-(2-oxoethyl)carbamic acid,ethyl ester (128740-03-4) → ethyl 1-benzyl-octahydropyrrolo[2,3-c]pyrrole-5-carboxylate (132414-78-9,894853-99-7)

Guidance literature:

In toluene;

upstream raw materials:

N-benzylglycine

N-allyl-N-(2-oxoethyl)carbamic acid,ethyl ester

ethyl N-(2,2-dimethoxyethyl)carbamate

ethyl N-(2,2-dimethoxyethyl)-N-(prop-2-en-1-yl)carbamate

Downstream raw materials:

tert-butyl 1-benzyl-octahydropyrrolo[2,3-c]pyrrole-5-carboxylate

tert-butyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate

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