4-(3,5-DIMETHYL-4H-1,2,4-TRIAZOL-4-YL)PIPERIDINE

Base Information

• Chemical Name: 4-(3,5-DIMETHYL-4H-1,2,4-TRIAZOL-4-YL)PIPERIDINE
• CAS No.: 795310-52-0
• Molecular Formula: C₉H₁₆N₄
• Molecular Weight: 180.253
• Hs Code.: 2933990090
• Mol file: 795310-52-0.mol

Synonyms:4-(3,5-Dimethyl-4H-1,2,4-triazol-4-yl)piperidine

Chemical Property of 4-(3,5-DIMETHYL-4H-1,2,4-TRIAZOL-4-YL)PIPERIDINE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: 300.939oC at 760 mmHg
• PKA: 9.87±0.10(Predicted)
• Flash Point: 135.804oC
• PSA: 42.74000
• Density: 1.072g/cm3
• LogP: 1.14820
• Storage Temp.: 2-8°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

97% ^*data from raw suppliers

4-(3,5-dimethyl-4H-1,2,4-triazol-4-yl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is employed as intermediate for pharmaceutical.

Technology Process of 4-(3,5-DIMETHYL-4H-1,2,4-TRIAZOL-4-YL)PIPERIDINE

There total 6 articles about 4-(3,5-DIMETHYL-4H-1,2,4-TRIAZOL-4-YL)PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.7%

1-benzyl-4-(3,5-dimethyl-[1,2,4]triazol-4-yl)-piperidine (280111-37-7) → 4-(3,5-dimethyl-[1,2,4]triazol-4-yl)-piperidine (795310-52-0)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; at 40 ℃; for 12h; under 2068.65 Torr;

Reference yield:

4-acetylamino-1-benzylpiperidine (50534-23-1) → 4-(3,5-dimethyl-[1,2,4]triazol-4-yl)-piperidine (795310-52-0)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine; trichlorophosphate / chloroform / 12 h / 0 - 20 °C

2: chloroform / 5 h / Reflux

3: hydrogenchloride / 12 h / Reflux

4: hydrogen; 10 wt% Pd(OH)2 on carbon / 12 h / 40 °C / 2068.65 Torr

With pyridine; hydrogenchloride; 10 wt% Pd(OH)2 on carbon; hydrogen; trichlorophosphate; In chloroform;

Reference yield:

N-(1-benzyl-piperidin-4-yl)-acetimidoyl chloride → 4-(3,5-dimethyl-[1,2,4]triazol-4-yl)-piperidine (795310-52-0)

Guidance literature:

Multi-step reaction with 3 steps

1: chloroform / 5 h / Reflux

2: hydrogenchloride / 12 h / Reflux

3: hydrogen; 10 wt% Pd(OH)2 on carbon / 12 h / 40 °C / 2068.65 Torr

With hydrogenchloride; 10 wt% Pd(OH)2 on carbon; hydrogen; In chloroform;

upstream raw materials:

1-benzyl-4-(3,5-dimethyl-[1,2,4]triazol-4-yl)-piperidine

4-acetylamino-1-benzylpiperidine

(Z)-N'-(1-(1-benzylpiperidin-4-ylimino)ethyl)acetohydrazide

4-amino-1-benzylpiperidine