280111-37-7

Upstream product

• 1068-57-1 acetic acid hydrazide 
• 50534-23-1 4-acetylamino-1-benzylpiperidine 
• 50541-93-0 4-amino-1-benzylpiperidine 
• 1421071-14-8 (Z)-N'-(1-(1-benzylpiperidin-4-ylimino)ethyl)acetohydrazide 

Downstream Products

• 795310-52-0 4-(3,5-dimethyl-[1,2,4]triazol-4-yl)-piperidine 

Relevant academic research and scientific papers

CHEMOKING RECEPTOR ANTAGONISTS

Disclosed herein are chemokine receptor antagonists of formula (I) wherein G1, X1, X2, and X3 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.

TRIAZOLYLPIPERIDINE DERIVATIVES AND USE THEREOF IN THERAPY

The present invention provides compounds of formula (I) Wherein R1 , R2, R3 , R4 , Het and m are as defined in the description. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors.

A practical synthesis of piperidine-/tropane-substituted 1,2,4-triazoles

A robust synthesis of 1,2,4-triazoles is disclosed with a particular focus on developing methodology capable of delivering gram quantities and minimising hazardous waste.

CHEMICAL COMPOUNDS

Compounds of formula (I): compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).