2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile

Base Information

Chemical Name:2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
CAS No.:675126-27-9
Molecular Formula:C15H21N3O3
Molecular Weight:291.35
Hs Code.:2933599090
DSSTox Substance ID:DTXSID70435047
Wikidata:Q72438772
Mol file:675126-27-9.mol

Synonyms:2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile;675126-27-9;2-amino-4-methoxy-5-(3-morpholin-4-ylpropoxy)benzonitrile;Benzonitrile, 2-amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]-;BORICACID-D3;SCHEMBL3281444;DTXSID70435047;DSPAUOALMSIBJA-UHFFFAOYSA-N;BCP14160;MFCD11110477;AKOS015895491;DS-3946;AC-26437;AM20090610;CS-0022482;FT-0711059;I11587;A867250;2-Amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]benzonitrile

Suppliers and Price of 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 95+%
25g
$ 317.00

Chemenu
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 95%
25g
$ 299.00

Chemenu
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 95%
10g
$ 163.00

Chemenu
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 95%
5g
$ 102.00

Ambeed
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 97%
5g
$ 87.00

Ambeed
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 97%
1g
$ 33.00

Ambeed
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 97%
250mg
$ 13.00

Ambeed
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 97%
25g
$ 279.00

Ambeed
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 97%
10g
$ 139.00

Alichem
2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
10g
$ 161.60

Total 64 raw suppliers

Chemical Property of 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile

Chemical Property:

Melting Point:88℃
Boiling Point:497.986 °C at 760 mmHg
PKA:7.08±0.10(Predicted)
Flash Point:254.973 °C
PSA：80.74000
Density:1.214 g/cm³
LogP:1.76928
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:291.15829154
Heavy Atom Count:21
Complexity:351

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C(=C1)N)C#N)OCCCN2CCOCC2

Technology Process of 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile

There total 7 articles about 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 675126-26-8
2-nitro-4-methoxy-5-[3-(morpholin-4-yl)propoxy]benzonitrile

: 675126-27-9
2-amino-4-methoxy-5-[(3-morpholin-4-yl)propoxy]benzonitrile

Guidance literature:: With sodium dithionite; In water; at 50 ℃; for 2h;

Reference yield:

: 675126-28-0
4-methoxy-3-[3-(morpholin-4-yl)propoxy]benzonitrile

: 675126-27-9
2-amino-4-methoxy-5-[(3-morpholin-4-yl)propoxy]benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / aq. H₂SO₄; HNO₃; AcOH / 50 h / 20 °C

2: 75 percent / sodium dithionite / H₂O / 20 - 50 °C

With sodium dithionite; sulfuric acid; nitric acid; acetic acid; In water;
DOI:10.1016/j.bmcl.2006.04.080

Reference yield:

: 52805-46-6
2-methoxy-5-cyanophenol

: 675126-27-9
2-amino-4-methoxy-5-[(3-morpholin-4-yl)propoxy]benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / K₂CO₃ / dimethylformamide / 10 h / 85 °C

2: 95 percent / aq. H₂SO₄; HNO₃; AcOH / 50 h / 20 °C

3: 75 percent / sodium dithionite / H₂O / 20 - 50 °C

With sodium dithionite; sulfuric acid; nitric acid; potassium carbonate; acetic acid; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.04.080