3,4-Dichloropyridin-2-amine

Base Information

• Chemical Name: 3,4-Dichloropyridin-2-amine
• CAS No.: 188577-69-7
• Molecular Formula: C5H4 Cl2 N2
• Molecular Weight: 163.00500
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID60455330
• Wikidata: Q72467862
• Mol file: 188577-69-7.mol

Synonyms:3,4-dichloropyridin-2-amine;188577-69-7;2-Amino-3,4-dichloropyridine;2-PYRIDINAMINE, 3,4-DICHLORO-;3,4-DICHLORO-PYRIDIN-2-YLAMINE;SCHEMBL559525;DTXSID60455330;WLIWKYZJBIUWSG-UHFFFAOYSA-N;AMY11449;MFCD08272175;AKOS006286022;AB44396;AS-34872;CS-0051608;FT-0645962;A813246

Chemical Property of 3,4-Dichloropyridin-2-amine

Chemical Property:

• Vapor Pressure: 0.029mmHg at 25°C
• Melting Point: 93-95℃
• Boiling Point: 245.119oC at 760 mmHg
• Flash Point: 102.045oC
• PSA: 38.91000
• Density: 1.498g/cm3
• LogP: 2.55180
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 161.9751535
• Heavy Atom Count: 9
• Complexity: 99

Purity/Quality:

99% ^*data from raw suppliers

3,4-Dichloropyridin-2-amine 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C(C(=C1Cl)Cl)N

Technology Process of 3,4-Dichloropyridin-2-amine

There total 5 articles about 3,4-Dichloropyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-Amino-4-chloropyridine (19798-80-2) → 2-amino-3,4-dichloropyridine (188577-69-7) + 2-amino-3,4,5-trichloropyridine (55933-91-0) + 4,5-dichloro-2-aminopyridine (188577-68-6)

Guidance literature:

With hydrogenchloride; dihydrogen peroxide; In water; 1.) 0 deg C -> room temperature, 2.) room temperature, 4 h;

DOI:10.1080/00397919708004207

Reference yield:

2,3,4-trichloropyridine (55934-02-6) → 4-amino-2,3-dichloropyridine (184416-83-9) + 2-amino-3,4-dichloropyridine (188577-69-7)

Guidance literature:

With ammonia; at 160 ℃;

Reference yield:

3-deazauracil (626-03-9,84719-31-3) → 2-amino-3,4-dichloropyridine (188577-69-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen peroxide; water; hydrochloric acid

2: phosphoryl chloride / 130 °C

3: aqueous NH₃ / 160 °C

With hydrogenchloride; ammonium hydroxide; water; dihydrogen peroxide; trichlorophosphate;

upstream raw materials:

2,3,4-trichloropyridine

2-Amino-4-chloropyridine

3-deazauracil

3-chloro-pyridine-2,4-diol

Downstream raw materials:

3-chloro-4-(2-fluoro-4-nitrophenyloxy)pyridine-2-amine

C₂₅H₁₇ClF₂N₆O₃

N-(4-(2-amino-3-chloropyridine-4-oxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-methyl-6-oxo-3,4,5,6-tetrahydro-2H-pyrido[3,2-b][1,4]oxazine-7-formamide

N-(4-(2-amino-3-chloropyridine-4-oxy)-3-fluorophenyl)-2-(dimethylamino)-4-(4-fluorophenyl)-5-oxo-4,5-dihydro-thiazolo[5,4-b]pyridine-6-formamide

Refernces