TERT-BUTYL 4-(2-TERT-BUTOXY-2-OXOETHYL)PIPERAZINE-1-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 4-(2-TERT-BUTOXY-2-OXOETHYL)PIPERAZINE-1-CARBOXYLATE
• CAS No.: 180576-04-9
• Molecular Formula: C₁₅H₂₈N₂O₄
• Molecular Weight: 300.398
• Hs Code.: 2933599090
• Mol file: 180576-04-9.mol

Synonyms:tert-Butyl 4-(2-(tert-butoxy)-2-oxoethyl)piperazine-1-carboxylate;1-Piperazineaceticacid,4-[(1,1-dimethylethoxy)carbonyl]-,1,1-dimethylethyl ester;

Chemical Property of TERT-BUTYL 4-(2-TERT-BUTOXY-2-OXOETHYL)PIPERAZINE-1-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 366.998oC at 760 mmHg
• Flash Point: 175.754oC
• PSA: 59.08000
• Density: 1.062g/cm3
• LogP: 1.75660
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl4-(2-(tert-butoxy)-2-oxoethyl)piperazine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-(2-TERT-BUTOXY-2-OXOETHYL)PIPERAZINE-1-CARBOXYLATE

There total 2 articles about TERT-BUTYL 4-(2-TERT-BUTOXY-2-OXOETHYL)PIPERAZINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate (77278-40-1) + acetic acid tert-butyl ester (540-88-5) → tert-butyl 4-(2-(tert-butoxy)-2-oxoethyl)piperazine-1-carboxylate (180576-04-9)

Guidance literature:

acetic acid tert-butyl ester; With bis(2,2,6,6-tetramethyl-1-piperidyl)zinc; In toluene; at 20 ℃; for 1h; Microwave irradiation;

tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate; With [2,2]bipyridinyl; copper dichloride; In tetrahydrofuran; toluene; at 20 ℃; for 1h; Microwave irradiation;

DOI:10.1039/c3cc49296f

Reference yield: 87.0%

bromoacetic acid tert-butyl ester (5292-43-3) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(2-(tert-butoxy)-2-oxoethyl)piperazine-1-carboxylate (180576-04-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 12h;

Reference yield:

tert-butyl 4-(2-(tert-butoxy)-2-oxoethyl)piperazine-1-carboxylate (180576-04-9) → N'-(carboxymethyl)-piperazine (37478-58-3)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃; for 12h;

upstream raw materials:

bromoacetic acid tert-butyl ester

1-t-Butoxycarbonylpiperazine

tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate

acetic acid tert-butyl ester

Downstream raw materials:

N'-(carboxymethyl)-piperazine

Refernces

• 1、 -. "NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HBV INFECTION". Page/Page column 114; 115. . Retrieved 2018/09/25.
• 2、 McDonald, Stacey L.,Wang, Qiu. "Selective α-amination and α-acylation of esters and amides via dual reactivity of O-acylhydroxylamines toward zinc enolates". supporting information. p. 2535 - 2538. Retrieved 2014/03/21.