1,3-Difluoro-5-pentylbenzene

Base Information

• Chemical Name: 1,3-Difluoro-5-pentylbenzene
• CAS No.: 121219-25-8
• Molecular Formula: C11H14F2
• Molecular Weight: 184.229
• Hs Code.: 2903999090
• Mol file: 121219-25-8.mol

Synonyms:3,5-difluoro-1-pentylbenzene; 5-pentyl-1,3-difluorobenzene;

Chemical Property of 1,3-Difluoro-5-pentylbenzene

Chemical Property:

• Vapor Pressure: 0.54mmHg at 25°C
• Refractive Index: 1.463
• Boiling Point: 197.2 °C at 760 mmHg
• Flash Point: 58.4 °C
• PSA: 0.00000
• Density: 1.022 g/cm³
• LogP: 3.69750
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,3-Difluoro-5-pentylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,3-difluoro-5-pentylbenzene is a useful reactant for the preparation of a liquid crystal compound having high dielectric anisotropy.

Technology Process of 1,3-Difluoro-5-pentylbenzene

There total 7 articles about 1,3-Difluoro-5-pentylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3,5-difluoro-1-pent-1'-enylbenzene (121219-24-7) → 3,5-difluoro-1-pentylbenzene (121219-25-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In pentane; for 4h; Ambient temperature;

Reference yield: 53.0%

1-Bromopentane (110-53-2) + 3,5-difluorobromobenzene (461-96-1) → 3,5-difluoro-1-pentylbenzene (121219-25-8)

Guidance literature:

3,5-difluorobromobenzene; With magnesium; In tetrahydrofuran; for 1h; Inert atmosphere; Reflux;

1-Bromopentane; With dilithium tetrachlorocuprate; In tetrahydrofuran; for 48h; Reflux; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.04.118

Reference yield:

pentanal (110-62-3) → 3,5-difluoro-1-pentylbenzene (121219-25-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / 1.) magnesium, 2.) ammonium chloride / diethyl ether; tetrahydrofuran; H₂O / 2 h / Heating

2: phosphorus(V) oxide / pentane / Ambient temperature

3: 73 percent / H₂ / 5percent palladium-on-charcoal / pentane / 4 h / Ambient temperature

With phosphorus pentaoxide; ammonium chloride; hydrogen; magnesium; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; water; pentane;

upstream raw materials:

3,5-difluoro-1-pent-1'-enylbenzene

pentanal

3,5-difluorobromobenzene

1-(3,5-difluorophenyl)pentan-1-ol

Downstream raw materials:

2,6-difluoro-4-pentylbenzoic acid

4-cyano-3-fluorophenyl 2,6-difluoro-4-pentylbenzoate

4'S-[2,6-difluoro-4-pentylphenyl]ethynyl-4'-(2-methyl-1-butyl)biphenyl

C₁₁H₁₃F₂I

Refernces

• 1、 Herman, Jakub,Kula, Przemys?aw. "The synthesis of chiral fluorinated 4-alkyl-4′-[(4-alkylphenyl) ethynyl]biphenyls". . p. 3621 - 3623. Retrieved 2013/07/05.
• 2、 -. "FLUORINATED OLIGOPHENYLS AND THEIR USE IN LIQUID CRYSTAL MATERIALS". . . Retrieved 2008/06/13.