(6-chloropyrazin-2-yl)isopropylamine

Base Information

• Chemical Name: (6-chloropyrazin-2-yl)isopropylamine
• CAS No.: 951884-00-7
• Molecular Formula: C₇H₁₀ClN₃
• Molecular Weight: 171.63
• Hs Code.: 2933990090
• Mol file: 951884-00-7.mol

Synonyms:2-Chloro-6-(isopropylamino)pyrazine;

Chemical Property of (6-chloropyrazin-2-yl)isopropylamine

Chemical Property:

• Boiling Point: 270.1 °C at 760 mmHg
• Flash Point: 117.2 °C
• PSA: 37.81000
• Density: 1.22 g/cm³
• LogP: 2.02330
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-6-isopropylaminopyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Chloro-6-isopropylaminopyrazine

Technology Process of (6-chloropyrazin-2-yl)isopropylamine

There total 1 articles about (6-chloropyrazin-2-yl)isopropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2,6-dichloropyrazine (4774-14-5) + isopropylamine (75-31-0) → 6-chloro-N-isopropylpyrazin-2-amine (951884-00-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 60 ℃; for 24h;

Reference yield:

6-chloro-N-isopropylpyrazin-2-amine (951884-00-7) → 5-(3-(6-(isopropylamino)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,2,4-thiadiazol-3-amine (1401349-76-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0 - 20 °C

1.2: 0 - 20 °C

2.1: copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 90 °C / Inert atmosphere

With copper(l) iodide; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; n-heptane; ethylbenzene; N,N-dimethyl-formamide;

Reference yield:

6-chloro-N-isopropylpyrazin-2-amine (951884-00-7) → 5-(3-(6-(isopropylamino)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,2,4-thiadiazol-3-amine (1401349-77-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 0 - 20 °C

1.2: 0 - 20 °C

2.1: copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 90 °C / Inert atmosphere

3.1: trifluoroacetic acid / 0.5 h / 100 °C / Microwave irradiation

With copper(l) iodide; trifluoroacetic acid; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; n-heptane; ethylbenzene; N,N-dimethyl-formamide;

upstream raw materials:

2,6-dichloropyrazine

isopropylamine

Downstream raw materials:

5-(3-(6-(isopropylamino)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,2,4-thiadiazol-3-amine

5-(3-(6-(isopropylamino)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,2,4-thiadiazol-3-amine

tert-butyl (3-(3-(6-(isopropylamino)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,2,4-thiadiazol-5-yl)carbamate

3-(3-(6-(isopropylamino)pyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-1,2,4-thiadiazol-5-amine