N¹-benzyl-2-(diethylphosphono)acetamidine hydroiodide

Base Information

• Chemical Name: N¹-benzyl-2-(diethylphosphono)acetamidine hydroiodide
• CAS No.: 77679-12-0
• Molecular Formula: C₁₃H₂₁N₂O₃P*HI
• Molecular Weight: 412.208
• Mol file: 77679-12-0.mol

Synonyms:

Chemical Property of N¹-benzyl-2-(diethylphosphono)acetamidine hydroiodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-benzyl-2-(diethylphosphono)acetamidine hydroiodide

There total 3 articles about N¹-benzyl-2-(diethylphosphono)acetamidine hydroiodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-(diethylphosphono)-S-methylthioacetamidinium iodide + benzylamine (100-46-9) → N1-benzyl-2-(diethylphosphono)acetamidine hydroiodide (77679-12-0)

Guidance literature:

In ethanol; for 3h; Ambient temperature;

DOI:10.1039/P19810000433

Reference yield:

diethyl 1-cyanomethylphosphonate (2537-48-6) → N1-benzyl-2-(diethylphosphono)acetamidine hydroiodide (77679-12-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 23 percent / hydrogen sulphide, triethylamine / pyridine / 5 h / Ambient temperature

2: 75 percent / acetone / 0.42 h / Ambient temperature

3: 71 percent / ethanol / 3 h / Ambient temperature

With hydrogen sulfide; triethylamine; In pyridine; ethanol; acetone;

DOI:10.1039/P19810000433

Reference yield:

(2-amino-2-thioxoethyl)phosphonic acid diethyl ester (77679-10-8) → N1-benzyl-2-(diethylphosphono)acetamidine hydroiodide (77679-12-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / acetone / 0.42 h / Ambient temperature

2: 71 percent / ethanol / 3 h / Ambient temperature

In ethanol; acetone;

DOI:10.1039/P19810000433

upstream raw materials:

benzylamine

diethyl 1-cyanomethylphosphonate

(2-amino-2-thioxoethyl)phosphonic acid diethyl ester

Downstream raw materials:

N¹-benzyl-2-phosphonoacetamidine hydrochloride