77679-10-8Relevant articles and documents
Phosphorylated arginine analogue, synthesis method and application thereof
-
Paragraph 0070; 0071; 0072; 0073; 0074; 0075, (2017/05/23)
The invention discloses a phosphorylated arginine analogue, a synthesis method and application thereof, and relates to phosphorylated arginine analogues. The phosphorylated arginine analogue is characterized in that a phosphoryl acetamidine structure is adopted as a main body; the phosphorylated arginine analogue can be utilized as hapten for preparing an antibody used for recognizing pArg on protein; the antibody prepared from the phosphorylated arginine analogue has specificity of recognizing pArg, and cross reactivity with other common phosphorylation modification forms in protein is low; besides, a mouse polyclonal antibody prepared from the phosphorylated arginine analogue is mainly of IgG2a type, and can be used for screening monoclonal antibodies; and the phosphorylated arginine analogue can be further utilized as an inhibitor of protein phosphorylated arginine esterase, utilized as a biochemical reagent for studying biological functions of the protein phosphorylated arginine esterase, or a lead compound for medicinal development aimed at the protein phosphorylated arginine esterase.
Phosphorus-substituted carbothioamides
Kozlov,Odinets,Lyssenko,Churusova,Yarovenko,Petrovskii,Mastryukova
, p. 925 - 931 (2007/10/03)
A facile procedure was developed for the synthesis of phosphorus- substituted carbothioamides by the reaction of the corresponding nitriles with O,O-diisopropyl dithiophosphate in the presence of methanol. The structural features and hydrogen bonding in c
A convergent synthesis of Ro24-5913, a novel leukotriene D4 antagonist
Maehr, Hubert,Yang, Roxana
, p. 5445 - 5448 (2007/10/03)
A new and convergent synthesis of the leukotriene D4 antagonist Ro24-5913 (9) has been developed that can serve both for technical production and combinatorial structure optimization. The synthesis of 6, achieved in 90% yield, is described. The conversion of 6 to 9 has been disclosed previously.