(E)-5-Hydroxy-2-pentenenitrile

Base Information

• Chemical Name: (E)-5-Hydroxy-2-pentenenitrile
• CAS No.: 53778-56-6
• Molecular Formula: C₅H₇NO
• Molecular Weight: 97.1167
• Mol file: 53778-56-6.mol

Synonyms:

Chemical Property of (E)-5-Hydroxy-2-pentenenitrile

Chemical Property:

• Boiling Point: 251.7±23.0 °C(Predicted)
• PKA: 14.38±0.10(Predicted)
• Density: 1.016±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-5-Hydroxy-2-pentenenitrile

There total 2 articles about (E)-5-Hydroxy-2-pentenenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

[2,2-Diphenyl-[1,2]oxasilolan-(3Z)-ylidene]-acetonitrile → (E)-5-hydroxypent-2-enenitrile (53778-56-6)

Guidance literature:

With potassium fluoride; water; potassium hydrogencarbonate; In tetrahydrofuran; methanol; for 4h; Ambient temperature;

DOI:10.1016/S0040-4039(00)78457-7

Reference yield:

hydrogen cyanide (74-90-8) + 3-Butyn-1-ol (927-74-2) → (E)-5-hydroxypent-2-enenitrile (53778-56-6) + 4-hydroxy-2-methylenebutanenitrile (44565-26-6)

Guidance literature:

With Ni(phmep)2; 1,2-bis((diphenylphosphino)methyl)benzene; In benzene; at 120 ℃; for 18h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

upstream raw materials:

hydrogen cyanide

3-Butyn-1-ol

Refernces

• 1、 Jackson, W. Roy,Lovel, Craig G.,Perlmutter, Patrick,Smallridge, Andrew J.. "The Stereochemistry of Organometallic Compounds. XXXI Hydrocyanation of Alkynols". . p. 1099 - 1106. Retrieved 2007/10/02.