1,2,3,4-tetrahydro-6-methyl-3-oxo-2-phenyl-5-(α-methylene-β,β-diphenylpropanenitril-3-yl)-4-pyridazinecarboxylic acid ethyl ester

Base Information

• Chemical Name: 1,2,3,4-tetrahydro-6-methyl-3-oxo-2-phenyl-5-(α-methylene-β,β-diphenylpropanenitril-3-yl)-4-pyridazinecarboxylic acid ethyl ester
• CAS No.: 1296221-51-6
• Molecular Formula: C₃₀H₂₇N₃O₃
• Molecular Weight: 477.563
• Mol file: 1296221-51-6.mol

Synonyms:

Chemical Property of 1,2,3,4-tetrahydro-6-methyl-3-oxo-2-phenyl-5-(α-methylene-β,β-diphenylpropanenitril-3-yl)-4-pyridazinecarboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2,3,4-tetrahydro-6-methyl-3-oxo-2-phenyl-5-(α-methylene-β,β-diphenylpropanenitril-3-yl)-4-pyridazinecarboxylic acid ethyl ester

There total 1 articles about 1,2,3,4-tetrahydro-6-methyl-3-oxo-2-phenyl-5-(α-methylene-β,β-diphenylpropanenitril-3-yl)-4-pyridazinecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

5,6-diaza-1,4-dimethyl-7-oxo-2,2,6-triphenylsipro[2,4]hept-4-ene-1-carbonitrile (1100708-25-5) + chloroacetic acid ethyl ester (105-39-5) → 3-methyl-4-(α-methylene-β,β-diphenylpropanenitril-3-yl)-5-oxo-1-phenyl-3-pyrazoline-2-acetic acid ethyl ester (1296221-53-8) + 1,2,3,4-tetrahydro-6-methyl-3-oxo-2-phenyl-5-(α-methylene-β,β-diphenylpropanenitril-3-yl)-4-pyridazinecarboxylic acid ethyl ester (1296221-51-6)

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 120 ℃; for 1h;

DOI:10.1002/jhet.519

Reference yield: 35.0%

1,2,3,4-tetrahydro-6-methyl-3-oxo-2-phenyl-5-(α-methylene-β,β-diphenylpropanenitril-3-yl)-4-pyridazinecarboxylic acid ethyl ester (1296221-51-6) → 1-acetyl-1,2,3,4-tetrahydro-6-methyl-3-oxo-2-phenyl-5-(α-methylene-β,β-diphenylpropanenitril-3-yl)-4-pyridazinecarboxylic acid ethyl ester (1296221-67-4)

Guidance literature:

With pyridine; acetic anhydride; at 100 ℃; for 2h;

DOI:10.1002/jhet.519

upstream raw materials:

5,6-diaza-1,4-dimethyl-7-oxo-2,2,6-triphenylsipro[2,4]hept-4-ene-1-carbonitrile

chloroacetic acid ethyl ester

Downstream raw materials:

1-acetyl-1,2,3,4-tetrahydro-6-methyl-3-oxo-2-phenyl-5-(α-methylene-β,β-diphenylpropanenitril-3-yl)-4-pyridazinecarboxylic acid ethyl ester