6-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE

Base Information

• Chemical Name: 6-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE
• CAS No.: 16544-67-5
• Molecular Formula: C9H5F3N2O
• Molecular Weight: 214.147
• Hs Code.: 2933990090
• Mol file: 16544-67-5.mol

Synonyms:4(1H)-Quinazolinone, 6-(trifluoromethyl)-(9CI);6-(Trifluoromethyl)quinazolin-4-ol;

Chemical Property of 6-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE

Chemical Property:

• Vapor Pressure: 2.62E-05mmHg at 25°C
• Melting Point: 209-211℃
• Refractive Index: 1.565
• Boiling Point: 358 °C at 760 mmHg
• PKA: 0.25±0.20(Predicted)
• Flash Point: 170.3 °C
• PSA: 46.01000
• Density: 1.51 g/cm³
• LogP: 2.35420
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-(Trifluoromethyl)quinazolin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE

There total 7 articles about 6-(TRIFLUOROMETHYL)QUINAZOLIN-4(3H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

→ 7-bromo-6-methylthioquinazolin-4(3H)-one formic acid salt (117348-93-3) + 6-(trifluoromethyl)-3Η-quinazolin-4-one (16544-67-5)

Guidance literature:

Reference yield: 65.0%

formamide acetate + 2-amino-5-(trifluoromethyl)benzoic acid (83265-53-6) → 6-(trifluoromethyl)-3Η-quinazolin-4-one (16544-67-5)

Guidance literature:

In ethanol; at 140 ℃; for 1.33333h; Microwave irradiation;

Reference yield: 63.0%

2-amino-5-trifluoromethylbenzoic acid ethyl ester (1108668-05-8) + formamidine acetic acid (3473-63-0) → 6-(trifluoromethyl)quinazolin-4-ol (16544-67-5)

Guidance literature:

In formamide; at 120 - 130 ℃; for 4h; Inert atmosphere;

upstream raw materials:

2-amino-5-(trifluoromethyl)benzoic acid

formamide

2-amino-5-(trifluoromethyl)benzoic acid, hydrochloride

formamidine acetic acid

Downstream raw materials:

4-chloro-6-(trifluoromethyl)quinazoline

C₁₅H₁₆F₃N₃

3-cyclohexyl-6-(trifluoromethyl)quinazolin-4(3H)-one

3-⁽¹⁵⁾N-3-benzyl-6-(trifluoromethyl)quinazolin-4(3H)-one

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