2-Amino-cyclohexanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester

Base Information

Chemical Name:2-Amino-cyclohexanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester
CAS No.:220760-95-2
Molecular Formula:C₃₈H₄₉ClN₂O₈
Molecular Weight:697.269
Hs Code.:

2-Amino-cyclohexanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester

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Chemical Property of 2-Amino-cyclohexanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester

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Technology Process of 2-Amino-cyclohexanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester

There total 5 articles about 2-Amino-cyclohexanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-tert-Butoxycarbonylamino-cyclohexanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester

: 220760-95-2
2-Amino-cyclohexanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester

Guidance literature:: With trifluoroacetic acid; at 25 ℃;
DOI:10.1016/S0960-894X(98)00682-9

Reference yield:

: 220760-49-6,209128-50-7
N-tert-butoxycarbonyl-1-aminocyclohexane-2-carboxylic acid

: 220760-95-2
2-Amino-cyclohexanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: DCC, DMAP / CH₂Cl₂ / 0 - 25 °C

2: Pd(PPh₃)4, N-methylmorpholine / tetrahydrofuran / 25 °C

3: DCC, DMAP / CH₂Cl₂ / 0 - 25 °C

4: Zn, AcOH

5: TFA / 25 °C

With 4-methyl-morpholine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0960-894X(98)00682-9

Reference yield:

: 220760-72-5
2-tert-butoxycarbonylamino-cyclohexanecarboxylic acid 1-carboxy-3-methyl-butyl ester

: 220760-95-2
2-Amino-cyclohexanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DCC, DMAP / CH₂Cl₂ / 0 - 25 °C

2: Zn, AcOH

3: TFA / 25 °C

With dmap; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; In dichloromethane;
DOI:10.1016/S0960-894X(98)00682-9