Boc-2-amino-1-cyclohexanecarboxylic acid

Base Information

• Chemical Name: Boc-2-amino-1-cyclohexanecarboxylic acid
• CAS No.: 220760-49-6
• Molecular Formula: C12H21 N O4
• Molecular Weight: 243.303
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID90402933
• Mol file: 220760-49-6.mol

Synonyms:220760-49-6;Boc-2-amino-1-cyclohexanecarboxylic acid;2-((tert-Butoxycarbonyl)amino)cyclohexanecarboxylic acid;2-[(2-methylpropan-2-yl)oxycarbonylamino]cyclohexane-1-carboxylic Acid;2-{[(tert-butoxy)carbonyl]amino}cyclohexane-1-carboxylic acid;2-(tert-butoxycarbonylamino)cyclohexanecarboxylic acid;Boc-1,2-cis-ACHC-OH;2-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylic acid;2-[(TERT-BUTOXYCARBONYL)AMINO]CYCLOHEXANE-1-CARBOXYLIC ACID;SCHEMBL1444280;DTXSID90402933;QJEQJDJFJWWURK-UHFFFAOYSA-N;MFCD02258130;2-(5-INDOLE)PHENYLACETICACID;AKOS010055520;AB10884;PB47445;SB36785;SB37331;SB39159;AS-70162;FT-0679700;FT-0679707;FT-0679715;FT-0754759;EN300-84243;6-(AMINOMETHYL)-2-PYRIDINECARBOXYLICACID;(1S,2S)-2-(n-boc-amino)cyclohexanecarboxylic acid;J-500425;(1R,2S)-BOC-2-AMINOCYCLOHEXANECARBOXYLICACID;F1907-0949;Z1250169556;(1RS,2SR)-2-[(tert-butoxycarbonyl)amino]cyclohexanecarboxylic acid

Chemical Property of Boc-2-amino-1-cyclohexanecarboxylic acid

Chemical Property:

• PSA: 75.63000
• Density: 1.12
• LogP: 2.54540
• Storage Temp.: 2-8°C
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 243.14705815
• Heavy Atom Count: 17
• Complexity: 295

Purity/Quality:

99% ^*data from raw suppliers

2-{[(tert-Butoxy)carbonyl]amino}cyclohexane-1-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC1CCCCC1C(=O)O

Technology Process of Boc-2-amino-1-cyclohexanecarboxylic acid

There total 1 articles about Boc-2-amino-1-cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Methyl (1R,2R)-N-tert-butyloxycarbonyl-trans-2-aminocyclohexanecarboxylate → N-tert-butoxycarbonyl-1-aminocyclohexane-2-carboxylic acid (220760-49-6,209128-50-7)

Guidance literature:

With hydrogenchloride; aqueous H₂O₂; sodium sulfate; In methanol; water; ethyl acetate;

Reference yield: 95.5%

1-amino-3-methylbenzene (108-44-1) + N-tert-butoxycarbonyl-1-aminocyclohexane-2-carboxylic acid (220760-49-6,209128-50-7) → C19H28N2O3

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 10 ℃; for 8h;

Reference yield: 95.5%

4-methoxy-aniline (104-94-9) + N-tert-butoxycarbonyl-1-aminocyclohexane-2-carboxylic acid (220760-49-6,209128-50-7) → C19H28N2O4

Guidance literature:

With dmap; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In dichloromethane; at 0 - 10 ℃; for 8h;

Downstream raw materials:

2-tert-butoxycarbonylamino-cyclohexanecarboxylic acid 1-allyloxycarbonyl-3-methyl-butyl ester

2-tert-butoxycarbonylamino-cyclohexanecarboxylic acid 1-carboxy-3-methyl-butyl ester

(E)-(7R,13S,16S)-7-(3-Chloro-4-methoxy-benzyl)-16-isobutyl-13-((E)-(R)-1-methyl-3-phenyl-allyl)-1,3,4,4a,5,7,8,12,13,18a-decahydro-2H-14,17-dioxa-5,8-diaza-benzocyclohexadecene-6,9,15,18-tetraone

2-Amino-cyclohexanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester

Refernces