methyl (E)-3-(2-methoxy-5-pyrimidinyl)acrylate

Base Information

Chemical Name:methyl (E)-3-(2-methoxy-5-pyrimidinyl)acrylate
CAS No.:107166-90-5
Molecular Formula:C₉H₁₀N₂O₃
Molecular Weight:194.19
Hs Code.:
DSSTox Substance ID:DTXSID00444682
Wikidata:Q82262900

Synonyms:107166-90-5;Methyl (E)-3-(2-methoxypyrimidin-5-yl)prop-2-enoate;SCHEMBL9889434;DTXSID00444682;MTPXANRAVBFGIJ-ONEGZZNKSA-N;methyl (E)-3-(2-methoxy-5-pyrimidinyl)acrylate;Methyl (2E)-3-[2-(methyloxy)-5-pyrimidinyl]-2-propenoate

Suppliers and Price of methyl (E)-3-(2-methoxy-5-pyrimidinyl)acrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (E)-3-(2-methoxy-5-pyrimidinyl)acrylate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
XLogP3:0.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:194.06914219
Heavy Atom Count:14
Complexity:210

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=NC=C(C=N1)C=CC(=O)OC
Isomeric SMILES:COC1=NC=C(C=N1)/C=C/C(=O)OC

Technology Process of methyl (E)-3-(2-methoxy-5-pyrimidinyl)acrylate

There total 3 articles about methyl (E)-3-(2-methoxy-5-pyrimidinyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 101803-06-9
5-iodo-2-methoxypyrimidine

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 107166-90-5
(E)-methyl 3-(2-methoxy-5-pyrimidinyl)acrylate

Guidance literature:: With palladium diacetate; tetrabutyl-ammonium chloride; potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1h;
DOI:10.1021/jm980559y

Reference yield: 81.0%

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 14001-66-2
5-bromo-2-methoxypyrimidine

: 107166-90-5
(E)-methyl 3-(2-methoxy-5-pyrimidinyl)acrylate

Guidance literature:: With triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; at 130 ℃; for 3h; Inert atmosphere;

Reference yield:

: 931-63-5
2-methoxypyrimidine

: 107166-90-5
(E)-methyl 3-(2-methoxy-5-pyrimidinyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: TFA, trifluoroacetic anhydride, N-iodosuccinimide / 11 h / 80 °C

2: 88 percent / Pd(OAc)2, K₂CO₃, n-Bu₄NCl / dimethylformamide / 1 h / 80 °C

With palladium diacetate; N-iodo-succinimide; tetrabutyl-ammonium chloride; potassium carbonate; trifluoroacetic acid; trifluoroacetic anhydride; In N,N-dimethyl-formamide;
DOI:10.1021/jm980559y