2-((R)-2-{(S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-phenyl-propylcarbamoyl)-succinic acid 1-(4-nitro-benzyl) ester

Base Information

Chemical Name:2-((R)-2-{(S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-phenyl-propylcarbamoyl)-succinic acid 1-(4-nitro-benzyl) ester
CAS No.:211689-78-0
Molecular Formula:C₄₁H₄₂N₆O₉
Molecular Weight:762.819
Hs Code.:

2-((R)-2-{(S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-phenyl-propylcarbamoyl)-succinic acid 1-(4-nitro-benzyl) ester

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Chemical Property of 2-((R)-2-{(S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-phenyl-propylcarbamoyl)-succinic acid 1-(4-nitro-benzyl) ester

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Technology Process of 2-((R)-2-{(S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-phenyl-propylcarbamoyl)-succinic acid 1-(4-nitro-benzyl) ester

There total 4 articles about 2-((R)-2-{(S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-phenyl-propylcarbamoyl)-succinic acid 1-(4-nitro-benzyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 211689-63-3
(2-{2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-phenyl-propyl)-carbamic acid benzyl ester

: 211689-78-0
2-((R)-2-{(S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-phenyl-propylcarbamoyl)-succinic acid 1-(4-nitro-benzyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol; dimethylformamide

2: EDC*HCl; HOBt / dimethylformamide

3: TFA / CH₂Cl₂

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00841-1

Reference yield:

: 211689-77-9
2-(2-{2-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-phenyl-propylcarbamoyl)-succinic acid 4-tert-butyl ester 1-(4-nitro-benzyl) ester

: 211689-78-0
2-((R)-2-{(S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-phenyl-propylcarbamoyl)-succinic acid 1-(4-nitro-benzyl) ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(01)00841-1

Reference yield:

: 211689-79-1
2-(4-Nitrobenzyloxycarbonyl)succinic acid 4-tert-butyl ester

: 211689-78-0
2-((R)-2-{(S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-3-phenyl-propionylamino}-3-phenyl-propylcarbamoyl)-succinic acid 1-(4-nitro-benzyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: EDC*HCl; HOBt / dimethylformamide

2: TFA / CH₂Cl₂

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00841-1