1-((S)-3,3-dimethyl-1-((R)-2-(naphthalen-1-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)-3-((1R,2R)-2-(2,5-diphenyl-1H-pyrrol-1-yl)cyclohexyl)thiourea

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Chemical Name:1-((S)-3,3-dimethyl-1-((R)-2-(naphthalen-1-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)-3-((1R,2R)-2-(2,5-diphenyl-1H-pyrrol-1-yl)cyclohexyl)thiourea
CAS No.:1431561-59-9
Molecular Formula:C₄₃H₄₈N₄OS
Molecular Weight:668.946
Hs Code.:

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Chemical Property of 1-((S)-3,3-dimethyl-1-((R)-2-(naphthalen-1-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)-3-((1R,2R)-2-(2,5-diphenyl-1H-pyrrol-1-yl)cyclohexyl)thiourea

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Technology Process of 1-((S)-3,3-dimethyl-1-((R)-2-(naphthalen-1-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)-3-((1R,2R)-2-(2,5-diphenyl-1H-pyrrol-1-yl)cyclohexyl)thiourea

There total 3 articles about 1-((S)-3,3-dimethyl-1-((R)-2-(naphthalen-1-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)-3-((1R,2R)-2-(2,5-diphenyl-1H-pyrrol-1-yl)cyclohexyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₆N₂O*ClH

: 1431561-59-9
1-((S)-3,3-dimethyl-1-((R)-2-(naphthalen-1-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)-3-((1R,2R)-2-(2,5-diphenyl-1H-pyrrol-1-yl)cyclohexyl)thiourea

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / water; dichloromethane / 0.5 h / 0 °C / Inert atmosphere

2: dichloromethane / 14 h / 23 °C / Inert atmosphere

With sodium hydrogencarbonate; In dichloromethane; water;
DOI:10.1021/ja402893z

Reference yield:

: C₂₅H₃₄N₂O₃

: 1431561-59-9
1-((S)-3,3-dimethyl-1-((R)-2-(naphthalen-1-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)-3-((1R,2R)-2-(2,5-diphenyl-1H-pyrrol-1-yl)cyclohexyl)thiourea

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 23 °C / Inert atmosphere

2: sodium hydrogencarbonate / water; dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3: dichloromethane / 14 h / 23 °C / Inert atmosphere

With hydrogenchloride; sodium hydrogencarbonate; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/ja402893z