C₂₈H₂₉F₂N₉OS

Base Information

• Chemical Name: C₂₈H₂₉F₂N₉OS
• CAS No.: 1111265-90-7
• Molecular Formula: C₂₈H₂₉F₂N₉OS
• Molecular Weight: 577.661
• Mol file: 1111265-90-7.mol

Synonyms:

Chemical Property of C₂₈H₂₉F₂N₉OS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₂₉F₂N₉OS

There total 9 articles about C₂₈H₂₉F₂N₉OS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C8H8IN3S (1094070-47-9) → C28H29F2N9OS (1111265-90-7)

Guidance literature:

Multi-step reaction with 8 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane

2: sodium hydride / N,N-dimethyl-formamide

3: sodium hydride / N,N-dimethyl-formamide

4: diisobutylaluminium hydride / tetrahydrofuran / -78 °C

5: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

6: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 90 °C

7: trifluoroacetic acid / dichloromethane

8: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; sodium tris(acetoxy)borohydride; sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 6: Suzuki-Miyaura coupling;

DOI:10.1016/j.bmcl.2012.03.051

Reference yield:

6-bromo-8-methylsulfanyl-imidazo[1,2-a]pyrazine (887475-71-0) → C28H29F2N9OS (1111265-90-7)

Guidance literature:

Multi-step reaction with 10 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / N,N-dimethyl-formamide / 100 °C

2: N-iodo-succinimide / N,N-dimethyl-formamide / 60 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane

4: sodium hydride / N,N-dimethyl-formamide

5: sodium hydride / N,N-dimethyl-formamide

6: diisobutylaluminium hydride / tetrahydrofuran / -78 °C

7: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

8: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 90 °C

9: trifluoroacetic acid / dichloromethane

10: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium tris(acetoxy)borohydride; sodium hydride; diisobutylaluminium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 8: Suzuki-Miyaura coupling;

DOI:10.1016/j.bmcl.2012.03.051

Reference yield:

C8H9N3S (1094070-46-8) → C28H29F2N9OS (1111265-90-7)

Guidance literature:

Multi-step reaction with 9 steps

1: N-iodo-succinimide / N,N-dimethyl-formamide / 60 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane

3: sodium hydride / N,N-dimethyl-formamide

4: sodium hydride / N,N-dimethyl-formamide

5: diisobutylaluminium hydride / tetrahydrofuran / -78 °C

6: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

7: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 90 °C

8: trifluoroacetic acid / dichloromethane

9: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; N-iodo-succinimide; sodium tris(acetoxy)borohydride; sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; HATU; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 7: Suzuki-Miyaura coupling;

DOI:10.1016/j.bmcl.2012.03.051

upstream raw materials:

6-bromo-8-methylsulfanyl-imidazo[1,2-a]pyrazine

C₈H₉N₃S

C₈H₈IN₃S

C₈H₈IN₃O₂S

Refernces