butyl 2-acetylamino-3-(4-nitrophenyl)propanoate

Base Information

• Chemical Name: butyl 2-acetylamino-3-(4-nitrophenyl)propanoate
• CAS No.: 1575603-81-4
• Molecular Formula: C₁₅H₂₀N₂O₅
• Molecular Weight: 308.334
• Mol file: 1575603-81-4.mol

Synonyms:

Chemical Property of butyl 2-acetylamino-3-(4-nitrophenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of butyl 2-acetylamino-3-(4-nitrophenyl)propanoate

There total 10 articles about butyl 2-acetylamino-3-(4-nitrophenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

butyl butyrate (109-21-7) + allyl 2-acetylamino-3-(4-nitrophenyl)propanoate (1575618-78-8) → butyl 2-acetylamino-3-(4-nitrophenyl)propanoate (1575603-81-4) + allyl 2-acetylamino-3-(4-nitrophenyl)propanoate (1575603-84-7)

Guidance literature:

With Rhizomucor miehei lipase; In acetonitrile; at 30 ℃; for 30h; enantioselective reaction; Inert atmosphere; Enzymatic reaction;

DOI:10.1016/j.tet.2014.02.012

Reference yield:

butyl butyrate (109-21-7) + 2-acetylamino-3-(4-nitro-phenyl)-propionic acid methyl ester (127090-51-1) → butyl 2-acetylamino-3-(4-nitrophenyl)propanoate (1575603-81-4) + (S)-methyl 2-acetamido-3-(4-nitrophenyl)propanoate (36097-39-9) + methyl (R)-2-acetamido-3-(4-nitrophenyl)propanoate (88546-12-7)

Guidance literature:

With Rhizomucor miehei lipase; In acetonitrile; at 30 ℃; for 120h; enantioselective reaction; Inert atmosphere; Enzymatic reaction;

DOI:10.1016/j.tet.2014.02.012

Reference yield:

C12H14N2O4*ClH (1575605-05-8) → butyl 2-acetylamino-3-(4-nitrophenyl)propanoate (1575603-81-4) + allyl 2-acetylamino-3-(4-nitrophenyl)propanoate (1575603-84-7)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; dmap / dichloromethane / 4 h / 20 °C

2: Rhizomucor miehei lipase / acetonitrile / 30 h / 30 °C / Inert atmosphere; Enzymatic reaction

With Rhizomucor miehei lipase; pyridine; dmap; In dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2014.02.012

upstream raw materials:

2-amino-3-(4-nitrophenyl)propionic acid hydrochloride

(+)-Methyl 2-amino-3-(4-nitrophenyl)propionate hydrochloride

C₁₂H₁₄N₂O₄*ClH

butyl butyrate