Azido-PEG11-amine

Base Information

• Chemical Name: Azido-PEG11-amine
• CAS No.: 1800414-71-4
• Molecular Formula: C₂₄H₅₀N₄O₁₁
• Molecular Weight: 570.681
• Hs Code.: 2942000090
• Mol file: 1800414-71-4.mol

Synonyms:

Chemical Property of Azido-PEG11-amine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Azido-PEG11-Amine >93.0%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Azido-PEG11-amine is a water soluble PEG compound. The azide group enables Click Chemistry. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG arm increases solubility in aqueous media.

Technology Process of Azido-PEG11-amine

There total 3 articles about Azido-PEG11-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

dodecaethylene glycol bisazide (1392284-57-9) → α-amino-ω-azido-α,ω-dideoxydodeca(ethylene glycol) (1800414-71-4)

Guidance literature:

dodecaethylene glycol bisazide; With hydrogenchloride; In water; at 0 ℃; for 0.5h; Schlenk technique;

With triphenylphosphine; In diethyl ether; water; at 0 - 20 ℃; for 50h;

DOI:10.1002/chem.201700555

Reference yield:

2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol (86770-67-4) → α-amino-ω-azido-α,ω-dideoxydodeca(ethylene glycol) (1800414-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

2.1: hydrogenchloride / water / 0.5 h / 0 °C / Schlenk technique

2.2: 50 h / 0 - 20 °C

With hydrogenchloride; sodium hydride; In water; N,N-dimethyl-formamide;

DOI:10.1002/chem.201700555

Reference yield:

tetraethylene glycol di(p-toluenesulfonate) (37860-51-8) → α-amino-ω-azido-α,ω-dideoxydodeca(ethylene glycol) (1800414-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

2.1: hydrogenchloride / water / 0.5 h / 0 °C / Schlenk technique

2.2: 50 h / 0 - 20 °C

With hydrogenchloride; sodium hydride; In water; N,N-dimethyl-formamide;

DOI:10.1002/chem.201700555

upstream raw materials:

dodecaethylene glycol bisazide

2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol

tetraethylene glycol di(p-toluenesulfonate)

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