Azido-PEG12-azide

Base Information

• Chemical Name: Azido-PEG12-azide
• CAS No.: 1392284-57-9
• Molecular Formula: C₂₄H₄₈N₆O₁₁
• Molecular Weight: 596.679
• Mol file: 1392284-57-9.mol

Synonyms:

Chemical Property of Azido-PEG12-azide

Chemical Property:

Purity/Quality:

99.3% ^*data from raw suppliers

Azido-PEG11-azide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Azido-PEG11-azide is a aqueous soluble, monodisperse PEG linker containing two azide groups.The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

Technology Process of Azido-PEG12-azide

There total 6 articles about Azido-PEG12-azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

tetraethylene glycol di(p-toluenesulfonate) (37860-51-8) + 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol (86770-67-4) → dodecaethylene glycol bisazide (1392284-57-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

DOI:10.1002/chem.201700555

Reference yield: 60.0%

2-[2-(2-azidoethoxy)ethoxy]ethanol (86520-52-7) + 3,6,9,12,15-pentaoxaheptadecane-1,17-diyl dimethanesulfonate (109789-40-4) → dodecaethylene glycol bisazide (1392284-57-9)

Guidance literature:

With sodium hydride; for 12h;

DOI:10.1016/j.tetlet.2004.04.004

Reference yield:

2-[2-(chloroethoxy)ethoxy]ethanol (5197-62-6) → dodecaethylene glycol bisazide (1392284-57-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / sodium azide / dimethylformamide / 4 h / 80 °C

2: 60 percent / sodium hydride / 12 h

With sodium azide; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2004.04.004

upstream raw materials:

2-[2-(2-azidoethoxy)ethoxy]ethanol

3,6,9,12,15-pentaoxaheptadecane-1,17-diyl dimethanesulfonate

pentaethylene glycol

2-[2-(chloroethoxy)ethoxy]ethanol

Downstream raw materials:

α-amino-ω-azido-α,ω-dideoxydodeca(ethylene glycol)