7-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-N-((S)-2,3-dihydro-1H-inden-1-yl)thieno[3,2-d]pyrimidin-4-amine

Base Information

Chemical Name:7-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-N-((S)-2,3-dihydro-1H-inden-1-yl)thieno[3,2-d]pyrimidin-4-amine
CAS No.:1370007-73-0
Molecular Formula:C₃₉H₄₃N₃O₄SSi
Molecular Weight:677.94
Hs Code.:

7-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-N-((S)-2,3-dihydro-1H-inden-1-yl)thieno[3,2-d]pyrimidin-4-amine

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Chemical Property of 7-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-N-((S)-2,3-dihydro-1H-inden-1-yl)thieno[3,2-d]pyrimidin-4-amine

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Technology Process of 7-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-N-((S)-2,3-dihydro-1H-inden-1-yl)thieno[3,2-d]pyrimidin-4-amine

There total 5 articles about 7-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-N-((S)-2,3-dihydro-1H-inden-1-yl)thieno[3,2-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370007-65-0
2-((3aS,6R,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-3-(dimethylamino)acrylonitrile

: 1370007-73-0
7-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-N-((S)-2,3-dihydro-1H-inden-1-yl)thieno[3,2-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / chloroform; water / 20 °C

2: triethylamine / dichloromethane / 1.17 h / 0 °C

3: sodium carbonate / ethanol / 6 h / Inert atmosphere; Reflux

4: toluene / 4 h / 110 °C

5: pyridine; acetic acid / acetonitrile / 0.5 h / 110 °C / Microwave irradiation

With pyridine; sodium carbonate; acetic acid; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; chloroform; water; toluene; acetonitrile;

Reference yield:

: 96690-02-7
5-O-(tert-butyldiphenylsilyl)-2,3-O-isopropylidene-D-ribofuranose

: 1370007-73-0
7-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-N-((S)-2,3-dihydro-1H-inden-1-yl)thieno[3,2-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / 0.17 h / 0 °C

1.2: 2 h / 20 °C

2.1: N,N-dimethyl-formamide / 20 °C

3.1: trifluoroacetic acid / chloroform; water / 20 °C

4.1: triethylamine / dichloromethane / 1.17 h / 0 °C

5.1: sodium carbonate / ethanol / 6 h / Inert atmosphere; Reflux

6.1: toluene / 4 h / 110 °C

7.1: pyridine; acetic acid / acetonitrile / 0.5 h / 110 °C / Microwave irradiation

With pyridine; sodium hydride; sodium carbonate; acetic acid; triethylamine; trifluoroacetic acid; In 1,2-dimethoxyethane; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 1370007-62-7
2-((3aS,6R,6aR)-6-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)acetonitrile

: 1370007-73-0
7-((3aS,4S,6R,6aR)-6-((tert-butyldiphenylsilyloxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-N-((S)-2,3-dihydro-1H-inden-1-yl)thieno[3,2-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1: N,N-dimethyl-formamide / 20 °C

2: trifluoroacetic acid / chloroform; water / 20 °C

3: triethylamine / dichloromethane / 1.17 h / 0 °C

4: sodium carbonate / ethanol / 6 h / Inert atmosphere; Reflux

5: toluene / 4 h / 110 °C

6: pyridine; acetic acid / acetonitrile / 0.5 h / 110 °C / Microwave irradiation

With pyridine; sodium carbonate; acetic acid; triethylamine; trifluoroacetic acid; In ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene; acetonitrile;